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Titolo:
In vitro activity and post-antibiotic effect of quinupristin/dalfopristin (Synercid)
Autore:
Ling, TKW; Fung, KSC; Cheng, AFB;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Microbiol, Hong Kong, HongKong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples RChina oples R China
Titolo Testata:
CHEMOTHERAPY
fascicolo: 4, volume: 47, anno: 2001,
pagine: 243 - 249
SICI:
0009-3157(200107/08)47:4<243:IVAAPE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAM-POSITIVE BACTERIA; STAPHYLOCOCCUS-AUREUS; RP 59500; QUINUPRISTIN-DALFOPRISTIN; ENTEROCOCCUS-FAECIUM; SEMISYNTHETIC STREPTOGRAMIN; STREPTOCOCCUS-PNEUMONIAE; VANCOMYCIN; RESISTANCE; TEICOPLANIN;
Keywords:
in vitro activity; post-antibiotic effect; Synercid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ling, TKW Chinese Univ Hong Kong, Prince Wales Hosp, Dept Microbiol, Hong Kong, HongKong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong KongPeoples R China ina
Citazione:
T.K.W. Ling et al., "In vitro activity and post-antibiotic effect of quinupristin/dalfopristin (Synercid)", CHEMOTHERA, 47(4), 2001, pp. 243-249

Abstract

The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin andtetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphylococcus aureus, including methicillin-resistant strains, were low (MIC90 = 0.5 mg/l), and were comparable with those of vancomycin and teicoplanin. This compound was superior to the macrolides and highly active against Streptococcus pneumoniae (both penicillin-sensitive and penicillin-resistant strains), with MIC90 = 2 mg/l. It was also active against other streptococci, with MIC90 = 4 mg/l. However, this agent is less active against enterococci (MIC90 = 32 mg/l). Quinupristin/dalfopristin showed high activity against gram-positive anaerobes, including Clostridium spp., Peptococcus spp. and Peptostreptococcus spp., with MIC90 less than or equal to2 mg/l. Quinupristin/dalfopristin was also investigated for its post-antibiotic effect (PAE) and bactericidal kinetics against nine strains of gram-positive organisms, including staphylococci, enterococci and pneumococci. Exponentially growing (log phase) cultures were exposed to quinupristin/dalfopristin at 2 x MIG. Growth kinetics was evaluated using viable counting. The drug was uniformly bactericidal against pneumococci and staphylococci within 2 and 8 h of exposure, respectively. The killing activity against enterococci was weak; there was little or no reduction in bacterial count over 24 h of incubation. PAEs ranging from 2.13 to 3.28 h, 0.92 to 3.02 h and 1.89 to7.07 h were produced on the tested pneumococci, staphylococci and enterococci, respectively. This study showed that quinupristin/dalfopristin is a promising agent active against gram-positive bacteria. The prolonged PAEs also suggest that the drug could be used intermittently at more widely spaced dosing intervals against grampositive organisms. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:43:22