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Titolo:
Relationship of electrochemical oxidation of catechins on their antioxidant activity in microsomal lipid peroxidation
Autore:
Yang, B; Kotani, A; Arai, K; Kusu, F;
Indirizzi:
Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Hachioji Tokyo Japan 1920392 o 1920392, Japan Chinese Acad Tradit Chinese Med, Inst Chinese Mat Med, Beijing, Peoples R China Chinese Acad Tradit Chinese Med Beijing Peoples R China Peoples R China
Titolo Testata:
CHEMICAL & PHARMACEUTICAL BULLETIN
fascicolo: 6, volume: 49, anno: 2001,
pagine: 747 - 751
SICI:
0009-2363(200106)49:6<747:ROEOOC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN-BREAKING ANTIOXIDANTS; TEA CATECHINS; FLAVONOIDS; TANNINS; AUTOXIDATION; POLYPHENOLS; INHIBITION; LIVER;
Keywords:
catechin; oxidation potential; microsomal lipid peroxidation; lipophilicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kusu, F Tokyo Univ Pharm & Life Sci, Sch Pharm, 1432-1 Horinouchi, Hachioji, Tokyo1920392, Japan Tokyo Univ Pharm & Life Sci 1432-1 Horinouchi Hachioji Tokyo Japan 1920392
Citazione:
B. Yang et al., "Relationship of electrochemical oxidation of catechins on their antioxidant activity in microsomal lipid peroxidation", CHEM PHARM, 49(6), 2001, pp. 747-751

Abstract

The oxidation potentials of catechins were measured by employing flow-through column electrolysis. The oxidation potentials of catechins were shown to depend on their structures. At the same time, the antioxidant activity ofcatechins on NADPH-dependent lipid peroxidation in rat liver microsomes was evaluated. Catechins showed a 50% inhibition of lipid peroxidation in theconcentration range of 10-51 muM. Among those studied, galloylated catechins exhibited stronger antioxidant activities than those of nongalloylated catechins, A quantitative relationship has been obtained to describe the antioxidant activity of catechins: log IC50 (muM)=1.56+2.49E(1/2) (V)-0.29 logP (r=0.907), where IC50 represents the concentration for 50% inhibition oflipid peroxidation, E-1/2 represents the half-wave potential of the first oxidation wave, and P represents the octanol/water partition coefficient. This relationship suggested two important characteristics determining catechin antioxidant activity namely the ease of oxidation and the lipophilicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:22:42