Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Selective inhibition of fibroblast growth factor (FGF)-stimulated mitogenesis by a FGF receptor-1-derived phosphopeptide
Autore:
Dunican, DJ; Williams, EJ; Howell, FV; Doherty, P;
Indirizzi:
Univ London Kings Coll, Mol Neurobiol Grp, MRC Ctr Dev Neurobiol, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL l, London SE1 1UL, England
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 5, volume: 12, anno: 2001,
pagine: 255 - 264
SICI:
1044-9523(200105)12:5<255:SIOFGF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR RECEPTOR; SH2 DOMAIN; ADAPTER PROTEIN; BINDING-SITES; PHOSPHATIDYLINOSITOL HYDROLYSIS; SIGNAL-TRANSDUCTION; TYROSINE KINASES; STRUCTURAL BASIS; SNT PROTEIN; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Doherty, P Univ London Kings Coll, Mol Neurobiol Grp, MRC Ctr Dev Neurobiol, New Hunts House,4th Floor S Wing,Guys Campus,Lond, London SE1 1UL, England Univ London Kings Coll New Hunts House,4th Floor S Wing,Guys Campus,LondLondon England SE1 1UL
Citazione:
D.J. Dunican et al., "Selective inhibition of fibroblast growth factor (FGF)-stimulated mitogenesis by a FGF receptor-1-derived phosphopeptide", CELL GROWTH, 12(5), 2001, pp. 255-264

Abstract

The activated fibroblast growth factor receptor (FGFR)-1 is phosphorylatedon five tyrosine residues outside the catalytic site. Although one such residue, Tyr(730), is flanked by potential binding sites for phosphotyrosine-interacting molecules, a physiological role for this region is still controversial. We report that a cell-permeant phosphopeptide mimic of this site, FGFR(730)(p)Y, inhibits FGF-mediated mitogenesis in cells with no effect onresponses stimulated by other growth factors, A similar phosphopeptide corresponding to the phospholipase Cy binding site on the receptor had no effect on the mitogenic response, The FGFR(730)(p)Y peptide did not inhibit phosphorylation of p90/FRS2 or Erk, suggesting that it does not act by inhibiting the Erk-kinase cascade. However, the FGFR730(p)Y peptide bound She in amanner requiring both phospholylated tyrosine and a putative PTB domain binding determinant. These data suggest that the peptide might inhibit mitogenesis by competing with the corresponding site on the FGFR for the ability to bind Shc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:30:53