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Titolo:
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function
Autore:
Morita, Y; Maravei, DV; Bergeron, L; Wang, S; Perez, G; Tsutsumi, O; Taketani, Y; Asano, M; Horai, R; Korsmeyer, SJ; Iwakura, Y; Yuan, J; Tilly, JL;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Obstet & Gynecol,Vincent Ctr Reprod Biol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 nt Ctr Reprod Biol, Boston, MA 02114 USA Univ Tokyo, Fac Med, Dept Obstet & Gynecol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 pt Obstet & Gynecol, Tokyo 1138655, Japan Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA Univ Tokyo, Inst Med Sci, Ctr Expt Med, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 d Sci, Ctr Expt Med, Tokyo 1088639, Japan Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA DanaFarber Canc Inst Boston MA USA 02115 ol & AIDS, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 6, volume: 8, anno: 2001,
pagine: 614 - 620
SICI:
1350-9047(200106)8:6<614:CDPPGC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; OOCYTE APOPTOSIS; MICE DEFICIENT; GONADAL-DYSGENESIS; PROPHASE-I; MOUSE; BAX; BCL-2; CHEMOTHERAPY; CHROMOSOMES;
Keywords:
apoptosis; cell death; oocyte; ovary; caspase; ATM; Bax;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Tilly, JL Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Obstet & Gynecol,Vincent Ctr Reprod Biol, VBK137C-GYN,55 Fruit St, Boston, MA 02114 USAHarvard Univ VBK137C-GYN,55 Fruit St Boston MA USA 02114 114 USA
Citazione:
Y. Morita et al., "Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function", CELL DEAT D, 8(6), 2001, pp. 614-620

Abstract

It is well established that programmed cell death claims up to two-thirds of the oocytes produced during gametogenesis in the developing fetal ovaries, However, the mechanisms underlying prenatal germ cell loss in females remain poorly understood, Herein we report that caspase-11 null female mice are born with a reduced number of oocyte-containing primordial follicles, This phenotype is likely due to failed cytokine processing known to occur in caspase-11 mutants since neonatal female mice lacking both interleukin (IL)-1 alpha and IL-1 beta also exhibit a reduced endowment of primordial follicles, In addition, germ cell death in wild-type fetal ovaries cultured ex vivo is suppressed by either cytokine, likely via ligand activation of type 1 IL-1 receptors expressed in fetal germ cells, Normal oocyte endowment canbe restored in caspase-11 null female mice by simultaneous inactivation ofthe gene encoding the cell death executioner enzyme, caspase-2, However, caspase-2 deficiency cannot overcome gametogenic failure resulting from meiotic recombination defects in ataxia telangiectasia-mutated (Atm) null female mice, Thus, genetically distinct mechanisms exist for developmental deletion of oocytes via programmed cell death, one of which probably functions as a meiotic quality-control checkpoint that cannot be overridden.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:04:46