Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer
Autore:
Fadok, VA; Xue, D; Henson, P;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 ogram, Denver, CO 80206 USA Univ Colorado, Colorado, CO USA Univ Colorado Colorado CO USAUniv Colorado, Colorado, CO USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 6, volume: 8, anno: 2001,
pagine: 582 - 587
SICI:
1350-9047(200106)8:6<582:IPITDK>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; PLACENTAL ANTICOAGULANT PROTEIN; PERIPHERAL-BLOOD LYMPHOCYTES; APOPTOTIC CELLS; VITRONECTIN RECEPTOR; C-ELEGANS; CAENORHABDITIS-ELEGANS; MEMBRANE PHOSPHATIDYLSERINE; RECOGNITION MECHANISM; HUMAN MACROPHAGES;
Keywords:
phagocytosis; apoptosis; phosphatidylserine; receptor; cytokines;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Fadok, VA Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, D509,1400 Jackson St, Denver, CO 80206 USA Natl Jewish Med & Res Ctr D509,1400 Jackson St Denver CO USA 80206
Citazione:
V.A. Fadok et al., "If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer", CELL DEAT D, 8(6), 2001, pp. 582-587

Abstract

Recognition of phosphatidylserine (PtdSer) is essential for engulfment of apoptotic cells by mammalian phagocytes. Engagement of a new phosphatidylserine-specific receptor (PtdSerR) appears to be necessary for uptake of apoptotic cells. Many other mammalian receptors have been described to functionin the clearance of apoptotic cells. The emerging picture is that many of these receptors may provide the strong adhesion needed to increase the likelihood of contact between the PtdSerR and its phospholipid ligand, which isrequired for uptake. Furthermore, stimulation of this receptor on different types of phagocytes by apoptotic cells, PtdSer-containing liposomes or anIgM monoclonal anti-PtdSer antibody initiates release of TGF beta, known to be involved in the anti-inflammatory effects of apoptotic cells. Althoughhighly homologous genes exist in C. elegans and Drosophila melanogaster, their role in engulfment of apoptotic cells remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:58:32