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Titolo:
Phosphatidylserine, a death knell
Autore:
Schlegel, RA; Williamson, P;
Indirizzi:
Penn State Univ, Dept Biochem & Mol Biol, S Frear Lab 428, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 8, University Pk, PA 16802 USA Amherst Coll, Dept Biol, Amherst, MA 01002 USA Amherst Coll Amherst MA USA 01002 Coll, Dept Biol, Amherst, MA 01002 USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 6, volume: 8, anno: 2001,
pagine: 551 - 563
SICI:
1350-9047(200106)8:6<551:PADK>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; RED-BLOOD-CELLS; MEMBRANE PHOSPHOLIPID ASYMMETRY; BINDING CASSETTE TRANSPORTER-1; SYSTEMIC LUPUS-ERYTHEMATOSUS; MOUSE PERITONEAL-MACROPHAGES; TANGIER-DISEASE PATIENTS; APOPTOTIC T-LYMPHOCYTES; GPI-ANCHORED PROTEINS; IN-SITU DETECTION;
Keywords:
apoptosis; phosphatidylserine; membrane asymmetry; phagocytosis; macrophages; aminophospholipid translocase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
167
Recensione:
Indirizzi per estratti:
Indirizzo: Schlegel, RA Penn State Univ, Dept Biochem & Mol Biol, S Frear Lab 428, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 Pk, PA 16802 USA
Citazione:
R.A. Schlegel e P. Williamson, "Phosphatidylserine, a death knell", CELL DEAT D, 8(6), 2001, pp. 551-563

Abstract

Virtually every cell in the body restricts phosphatidylserine (PS) to the inner leaflet of the plasma membrane by energy-dependent transport from theouter to the inner leaflet of the bilayer, Apoptotic cells of all types rapidly randomize the asymmetric distribution, bringing PS to the surface where it serves as a signal for phagocytosis, A myriad of phagocyte receptors have been implicated in the recognition of apoptotic cells, among them a PSreceptor, yet few ligands other than PS have been identified on the apoptotic cell surface. Since apoptosis and the associated exposure of PS on the cell surface is probably over 600 million years old, it is not surprising that evolution has appropriated aspects of this process for specialized purposes such as blood coagulation, membrane fusion and erythrocyte differentiation, Failure to efficiently remove apoptotic cells may contribute to inflammatory responses and autoimmune diseases resulting from chronic, inappropriate exposure of PS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:15:26