Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estrogen receptor-alpha and -beta immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord
Autore:
Papka, RE; Storey-Workley, M; Shughrue, PJ; Merchenthaler, I; Collins, JJ; Usip, S; Saunders, PTK; Shupnik, M;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Neurobiol & Pharmacol, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 & Pharmacol, Rootstown, OH 44272 USA Wyeth Ayerst Res, Womens Hlth Res Inst, Radnor, PA USA Wyeth Ayerst Res Radnor PA USA Res, Womens Hlth Res Inst, Radnor, PA USA MRC, Ctr Reprod Biol, Reprod Unit, Edinburgh EH3 9EW, Midlothian, ScotlandMRC Edinburgh Midlothian Scotland EH3 9EW h EH3 9EW, Midlothian, Scotland Univ Virginia, Hlth Sci Ctr, Dept Med, Charlottesville, VA USA Univ Virginia Charlottesville VA USA , Dept Med, Charlottesville, VA USA
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 2, volume: 304, anno: 2001,
pagine: 193 - 214
SICI:
0302-766X(200105)304:2<193:ERA-IA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLION; GENE-RELATED PEPTIDE; MESSENGER-RNA LEVELS; NADPH-DIAPHORASE ACTIVITY; CENTRAL-NERVOUS-SYSTEM; RAT PREOPTIC AREA; FEMALE RAT; ER-ALPHA; GUINEA-PIG; AFFERENT-FIBERS;
Keywords:
pelvic ganglia; dorsal root ganglia; nodose ganglia; capsaicin receptor; vanilloid receptor; calcitonin gene-related peptide; rat (Sprague Dawley);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
109
Recensione:
Indirizzi per estratti:
Indirizzo: Papka, RE NE Ohio Univ, Coll Med, Dept Neurobiol & Pharmacol, POB 95,4209 State Rt 44, Rootstown, OH 44272 USA NE Ohio Univ POB 95,4209 State Rt 44 Rootstown OH USA 44272 USA
Citazione:
R.E. Papka et al., "Estrogen receptor-alpha and -beta immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord", CELL TIS RE, 304(2), 2001, pp. 193-214

Abstract

Estrogen receptor-alpha immunoreactivity and mRNAs are present in neurons in locales that innervate genital organs, e.g., parasympathetic pelvic autonomic ganglia, sensory dorsal root and nodose ganglia, and autonomic areas of the lumbosacral spinal cord. With the availability of probes for the beta -isoform of the estrogen receptor, we studied this receptor in autonomic,sensory, and spinal cord neurons and compared it with the distribution of the a-receptor. Estrogen receptor-alpha and -beta immunoreactivity were located in the nuclei of neurons, were in subpopulations of parasympathetic neurons in pelvic ganglia, and sensory neurons of dorsal root and nodose ganglia. Both receptor subtypes were present in the lumbosacral spinal cord: inneurons of the outer laminae of the dorsal horn, lateral collateral and medial collateral pathways, sacral parasympathetic nucleus, dorsal intermediate gray, and lamina X. Similar numbers of spinal cord neurons were immunoreactive for estrogen receptor-beta and estrogen receptor-alpha. However, estrogen receptor-beta -immunoreactive neurons appeared less numerous in the outer dorsal horn, but more numerous in the deeper layers of the spinal cordthan estrogen receptor-alpha neurons. Retrograde tracing from the uterus revealed "uterine-related" neurons in dorsal root and pelvic ganglia that contained estrogen receptor-alpha and -beta. In situ hybridization revealed both estrogen receptor-alpha and -beta mRNA transcripts in sensory neurons of the dorsal root and nodose ganglia, parasympathetic neurons of pelvic ganglia, and spinal cord neurons in the dorsal horn, sacral parasympathetic nucleus, and dorsal intermediate gray of L6-S1 segments. These studies show that both estrogen receptor-alpha and -beta are synthesized by autonomic andsensory neurons in parts of the nervous system that have connections with the female reproductive system. Such neurons contain neurotransmitters thathave important functions in the female reproductive organs; thus, it is likely that estrogen can influence the activity of such neurons and consequently, through them, the activities of the reproductive organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:23:18