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Titolo:
Surgical treatment of lung cancer after radiochemotherapy or chemotherapy.Risks and benefits
Autore:
Fuentes, P; Doddoli, C; Thomas, P; Giudicelli, R;
Indirizzi:
Hop St Marguerite, Serv Chirurg Thorac, F-13274 Marseille 09, France Hop St Marguerite Marseille France 09 orac, F-13274 Marseille 09, France
Titolo Testata:
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
fascicolo: 2, volume: 185, anno: 2001,
pagine: 387 - 404
SICI:
0001-4079(2001)185:2<387:STOLCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
FRE
Soggetto:
STAGE-IIIA; PREOPERATIVE CHEMOTHERAPY; NEOADJUVANT THERAPY; RANDOMIZED TRIAL; PHASE-II; MULTIMODALITY THERAPY; INDUCTION TREATMENT; RADIATION-THERAPY; INTERIM ANALYSIS; CELL;
Keywords:
lung neoplasms, surgery; lung neoplasms, drug therapy; lung neoplasms, radiotherapy adjuvants, pharmaceutic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fuentes, P Hop St Marguerite, Serv Chirurg Thorac, 270 Bld St Marguerite,BP 29, F-13274 Marseille 09, France Hop St Marguerite 270 Bld St Marguerite,BP 29 Marseille France 09
Citazione:
P. Fuentes et al., "Surgical treatment of lung cancer after radiochemotherapy or chemotherapy.Risks and benefits", B ACA N MED, 185(2), 2001, pp. 387-404

Abstract

The purpose of this study was to evaluate the conditions and results of lung cancer surgery following chemo and/or radiotherapy. This retrospective study included 69 patients treated from January 1990 to January 1998 for a primary lung cancer in whom surgery had been performed after induction treatment. Surgery had not been considered initially for the following reasons :NZ disease (n=25), temporary, functional impairment (n=4); doubtful resectability (n=40). The medical regimen resulted in combined radio-chemotherapyin 43 patients who received 2 to 4 sessions of chemotherapy (average=2.9 +/- 0.8 sessions) and 43 +/- 8 Gy (20 to 60 Gy), or chemotherapy alone in 26patients (3 +/- 0.7 sessions). Exploratory thoracotomy was performed in 4 patients (6 %). There were 33 pneumonectomies 1 bilobectomy, 23 lobectomiesand 8 lund sparing resections. The in-hospital mortality was 9 % (n=6) from respiratory origin in all cases. There were 4 reoperations (6 %) : 3 for bronchial fistula and 1 for bleeding Thirty five patients (51 %) required blood transfusion (4.5 +/- 3.8 cell packs). The incidence of early and delayed bronchial fistula after pneumonectomy was 15 %. Thirteen patients had a postoperative pneumonia (19 %). The overall 5 vears survival was 22 % [19-32]. In the group of patients who had a complete resection, five-years survival for patients classified pathologically as N0 or N1 was 31 % and for those classified as N2.8 % (p = 0.19). Surgical management after induction chemo and/or radiotherapy of NSC lung cancer should be considered. in the absence of N2 disease. Ir hen a complete resection is achievable. However this surgery is associated with an increased risk.

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Documento generato il 05/12/20 alle ore 19:50:43