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Titolo:
Vascular actions of MDMA involve alpha(1) and alpha(2)-adrenoceptors in the anaesthetized rat
Autore:
McDaid, J; Docherty, JR;
Indirizzi:
Royal Coll Surg Ireland, Dept Physiol, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 Dept Physiol, Dublin 2, Ireland
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 133, anno: 2001,
pagine: 429 - 437
SICI:
0007-1188(200106)133:3<429:VAOMIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECSTASY; BRAIN; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; METHYLENEDIOXYMETHAMPHETAMINE; VOLUNTEERS; CLONIDINE; SYSTEM; SITES;
Keywords:
anaesthetized rat; alpha(2)-adrenoceptors; alpha(1)-adrenoceptors; 5-HT2 receptors; methylenedioxymethamphetamine; MDMA; cocaine; methoxyidazoxan; methiothepin; prazosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: McDaid, J Royal Coll Surg Ireland, Dept Physiol, 123 St Stephens Green, Dublin 2, Ireland Royal Coll Surg Ireland 123 St Stephens Green Dublin Ireland 2
Citazione:
J. McDaid e J.R. Docherty, "Vascular actions of MDMA involve alpha(1) and alpha(2)-adrenoceptors in the anaesthetized rat", BR J PHARM, 133(3), 2001, pp. 429-437

Abstract

1 We have investigated the effects of methylenedioxymethamphetamine (MDMA,'ecstasy'), i.v., on diastolic blood pressure (DBP) in pithed and pentobarbitone anaesthetized rats.2 In pithed rats, the non-selective 5-HT receptor antagonist methiothepin (0.1 mg kg(-1)) and the alpha (2)-adrenoceptor antagonists methoxyidazoxan and yohimbine (1 mg kg(-1)) showed significant alpha (1)-adrenoceptor antagonist potency, but methiothepin did not show alpha (2)-adrenoceptor antagonist potency. MDMA (I and 5 mg kg(-1)) produced presser responses which weresignificantly reduced by the alpha (1)-adrenoceptor antagonist prazosin (0.1 mg kg(-1)), yohimbine (1 mg kg(-1)) or methiothepin (0.1 mg kg(-1)), butnot by the 5-HT2 receptor antagonist ritanserin (1 mg kg(-1)).3 In anaesthetized rats, antagonists revealed two phases with three components to the effects of MDMA (5 mg kg(-1)) on DBP: an initial presser response, a later presser component at 1 min, the sustained depressor response. Methoxyidazoxan, methiothepin or the combination ritanserin/prazosin significantly reduced the initial presser response, although neither of the lattercompounds alone had any effect.4 The presser response to MDMA (5 mg kg(-1)) at 1 min was converted to a depressor response by prazosin and to a lesser extent methiothepin and methoxyidazoxan.5 The depressor response to MDMA (5 mg kg(-1)) was significantly reduced by methoxyidazoxan (0.1 mg kg(-1)), and by the noradrenaline re-uptake blocker cocaine 10 mg kg(-1) but not I mg kg(-1) However, the most marked reduction in the depressor response was produced by the combination of methoxyidazoxan and cocaine.6 It is concluded that the initial presser response to MDMA (5 mg kg(-1)) in anaesthetized rats involves alpha (2)- and possibly alpha (1)-adrenoceptors and 5-HT2 receptors, the presser component at 1 min is largely alpha (1)-adrenoceptor mediated, and the sustained depressor response involves alpha (2)-adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:38:42