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Titolo:
Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
Autore:
Roy, HK; Karoski, WJ; Ratashak, A; Smyrk, TC;
Indirizzi:
Univ Nebraska, Med Ctr, Eppley Canc Inst, Dept Internal Med, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 , Dept Internal Med, Omaha, NE 68198 USA Mayo Clin, Dept Pathol, Rochester, MN USA Mayo Clin Rochester MN USAMayo Clin, Dept Pathol, Rochester, MN USA
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 10, volume: 84, anno: 2001,
pagine: 1412 - 1416
SICI:
0007-0920(20010518)84:10<1412:COITBN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; COLORECTAL-CANCER; GASTROINTESTINAL TOXICITY; MIN MOUSE; EXPRESSION; SULINDAC; CELLS; ASPIRIN; TUMORS; MODEL;
Keywords:
colon cancer; nonsteroidal anti-inflammatory drugs; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Roy, HK Univ Nebraska, Med Ctr, Eppley Canc Inst, Dept Internal Med, 982000 Nebraska Med Ctr, Omaha, NE 68198 USA Univ Nebraska 982000 Nebraska Med Ctr Omaha NE USA 68198 68198 USA
Citazione:
H.K. Roy et al., "Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation", BR J CANC, 84(10), 2001, pp. 1412-1416

Abstract

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancercells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. (C) 2001 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:03:39