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Titolo:
Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands
Autore:
Huang, YY; Kegeles, LS; Bae, SA; Hwang, DR; Roth, BL; Savage, JE; Laruelle, M;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Case Western Reserve Univ, Sch Med,NIMH, Psychoact Drug Screening Program,Dept Biochem, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med,NIMH, Psychoact Drug Screening Program,Dept Psychiat, Cleveland, OH 44106 USA Case Western Reserve Univ ClevelandOH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 11, volume: 11, anno: 2001,
pagine: 1375 - 1377
SICI:
0960-894X(20010604)11:11<1375:SOPASD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONHUMAN PRIMATE BRAIN; RECEPTOR ANTAGONIST; HIGH-AFFINITY; L-745,870; PROFILE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, YY Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 722 W 168th St New York NY USA 10032
Citazione:
Y.Y. Huang et al., "Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands", BIOORG MED, 11(11), 2001, pp. 1375-1377

Abstract

A series of dopamine D-4 antagonists was synthesized and evaluated as potential candidates for development as positron emission tomography (PET) radioligands. All new compounds display high affinity and selectivity for the D-4 receptors and compounds 5b, 5d, and 5e were identified as candidates forradioligand development. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:37:43