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Titolo:
Effect of serum triglyceride concentration on the fluctuation of whole blood concentration of cyclosporin A in patients
Autore:
Nakamura, T; Kakumoto, M; Sakaeda, T; Nagahiro, K; Ohmichi, R; Yamashita, K; Nishiguchi, K; Hirai, M; Okumura, K;
Indirizzi:
Kobe Univ, Sch Med, Dept Hosp Pharm, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 m, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Pharmaceut Univ, Dept Clin Pharm, Higashinada Ku, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 6588558 Kobe, Hyogo 6588558, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 6, volume: 24, anno: 2001,
pagine: 683 - 687
SICI:
0918-6158(200106)24:6<683:EOSTCO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTRIGLYCERIDEMIA; PHARMACOKINETICS; LIPOPROTEINS; ERYTHROCYTES; BINDING;
Keywords:
cyclosporin A (CYA); fluctuation of CYA trough blood concentration; serum triglyceride concentration; laboratory test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Okumura, K Kobe Univ, Sch Med, Dept Hosp Pharm, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 Kobe, Hyogo 6500017, Japan
Citazione:
T. Nakamura et al., "Effect of serum triglyceride concentration on the fluctuation of whole blood concentration of cyclosporin A in patients", BIOL PHAR B, 24(6), 2001, pp. 683-687

Abstract

The methodology to distinguish the patients showing considerable fluctuation of the whole blood concentration of cyclosporin A (CYA) was investigatedfrom a viewpoint of laboratory test values. First, we retrospectively examined the CYA trough blood concentrations monitored continuously. The patients were classified into three groups by the fluctuation of CYA trough bloodconcentrations during the examination period (C-max/C-min): Group 1 (C-max/C-min=100-200%; n=21), Group 2 (C-max/C-min=200-300%; n=25), and Group 3 (C-max/C-min=more than 300%; n=32), In the laboratory tests examined, the serum triglyceride concentrations were considerably different among the groups, and it was the highest in Group 3, Next, to elucidate the effect of serum triglyceride concentration on the CYA blood concentration, in vivo pharmacokinetic studies after single intravenous or repetitive oral administration of CYA were conducted in the model rats with pseudo-hypertriglyceridemia,hypocythemia, and acute renal failure, Only in pseudo-hypertriglyceridemiarats, the CYA blood concentration after a single intravenous injection wassignificantly higher than that in normal rats because of the restriction of CYA distribution to the extravascular tissues. On the other hand, the increase in the serum triglyceride concentration did not affect the fluctuation of CYA trough blood concentration after repetitive oral administration. Taken together, the fluctuation of CYA trough blood concentrations observed in the clinical situation could be due to the fluctuation of serum triglyceride concentration, and the patients with such fluctuation of serum triglyceride concentrations might also be distinguishable by the higher concentration of serum triglyceride in laboratory tests.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:46