Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Granulomatous tissue formation of shikon and shikonin by air pouch method
Autore:
Sakaguchi, I; Tsujimura, M; Ikeda, N; Minamino, M; Kato, Y; Watabe, K; Yano, I; Kaneda, K;
Indirizzi:
Club Cosmet Co Ltd, Inst Cosmet Sci, Nara 6300222, Japan Club Cosmet Co Ltd Nara Japan 6300222 st Cosmet Sci, Nara 6300222, Japan Japan BCG Lab, Tokyo 2040022, Japan Japan BCG Lab Tokyo Japan 2040022Japan BCG Lab, Tokyo 2040022, Japan Setsunan Univ, Fac Pharmaceut Sci, Dept Microbiol Publ Hlth, Hirakata, Osaka 5730101, Japan Setsunan Univ Hirakata Osaka Japan 5730101 Hirakata, Osaka 5730101, Japan Osaka City Univ, Sch Med, Dept Anat, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Anat, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 6, volume: 24, anno: 2001,
pagine: 650 - 655
SICI:
0918-6158(200106)24:6<650:GTFOSA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; COLONY-STIMULATING FACTOR; NEUTROPHIL KINETICS; GRANULATION-TISSUE; CELL; ACETYLSHIKONIN; ANGIOGENESIS; INVIVO; RAT;
Keywords:
shikon; shikonin; granulomatous tissue; neovascularization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaguchi, I Club Cosmet Co Ltd, Inst Cosmet Sci, 145-1 Ichibu Cho, Nara 6300222, Japan Club Cosmet Co Ltd 145-1 Ichibu Cho Nara Japan 6300222 Japan
Citazione:
I. Sakaguchi et al., "Granulomatous tissue formation of shikon and shikonin by air pouch method", BIOL PHAR B, 24(6), 2001, pp. 650-655

Abstract

"The extract of shikon" (SK) and shikonin play important roles in the development of granulomatous tissue formation. To reveal the augmenting effect of SK or shikonin on vascular endothelial growth factor (VEGF) production and neovascularization, we investigated murine granulomatous tissue induced by SK and shikonin, comparing them to pouches in which trehalose 6,6 ' -dimycolate (TDM) was injected, The development of granulomatous tissue formation was evaluated by the wet weight of pouch walls, At day 5 and 7 after SK and shikonin injection, prominent granulomatous tissue formation was detected. Histological observations on the development of granulomatous tissue showed that the pouch was formed in the submuscular connective tissue and necrotic tissue directly facing the cavity and granulomatous tissue developed in the connective tissue. At day 1, VEGF-positive neutrophils accumulated in the pouch wall. Granulomatous tissue formation and neovascularization by injection of SK or shikonin was not more prominent than TDM, However, the present results indicate that SK and shikonin induce neovascularization in granulomatous tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:03:14