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Titolo:
Effect of long term-administration with Gymnema sylvestre R. BR on plasma and liver lipid in rats
Autore:
Shigematsu, N; Asano, R; Shimosaka, M; Okazaki, M;
Indirizzi:
Shinshu Univ, Dept Appl Biol, Ueda, Nagano 3868567, Japan Shinshu Univ Ueda Nagano Japan 3868567 Biol, Ueda, Nagano 3868567, Japan Shinshu Univ, Gene Res Ctr, Ueda, Nagano 3868567, Japan Shinshu Univ UedaNagano Japan 3868567 s Ctr, Ueda, Nagano 3868567, Japan Nihon Univ, Coll Bioresource Sci, Dept Vet Pharmacol, Fujisawa, Kanagawa 2528510, Japan Nihon Univ Fujisawa Kanagawa Japan 2528510 isawa, Kanagawa 2528510, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 6, volume: 24, anno: 2001,
pagine: 643 - 649
SICI:
0918-6158(200106)24:6<643:EOLTWG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL; EXCRETION; CHITOSAN; LEAVES; ACIDS; DIET;
Keywords:
Gymnema sylvestre; chitosan; plasma lipid; liver lipid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Shigematsu, N Shinshu Univ, Dept Appl Biol, 3-15-1 Tokida, Ueda, Nagano 3868567, Japan Shinshu Univ 3-15-1 Tokida Ueda Nagano Japan 3868567 , Japan
Citazione:
N. Shigematsu et al., "Effect of long term-administration with Gymnema sylvestre R. BR on plasma and liver lipid in rats", BIOL PHAR B, 24(6), 2001, pp. 643-649

Abstract

Extract of Gymnema sylvestre leaves was administered to rats receiving either a high fat diet or normal fat diet for 10 weeks to investigate its influence on plasma and liver lipids and on visceral fat accumulation. In addition, its effect was compared with those of chitosan and the influence of combined use of these two substances was also evaluated. Within the high fat diet groups, the extract suppressed bod, weight gain and accumulation of liver lipids to the same extent as chitosan and the combined use. In addition, intraperitoneal fat and fat drop vacuoles on the epithelium of renal tubules, noted in the high fat diet group, were scattered by administration of the extract with the same results as for chitosan and combined use. Within the normal fat diet groups, plasma triglyceride levels decreased by administration of the extract, with similar results as chitosan and combined use. Concerning plasma total cholesterol, there was no decreasing effects with the extract, as found with chitosan and combined use. However, the effect ofchitosan on plasma total cholesterol tended to be enhanced when used in combination with the extract, In addition, long-term administration of the extract did not shun any influeuce on hematological and blood chemical parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:27:40