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Titolo:
REMODELING OF REGULATORY NUCLEOPROTEIN COMPLEXES ON THE XENOPUS HSP70PROMOTER DURING MEIOTIC MATURATION OF THE XENOPUS OOCYTE
Autore:
LANDSBERGER N; WOLFFE AP;
Indirizzi:
NICHHD,MOL EMBRYOL LAB,NIH,BLDG 18T,ROOM 106 BETHESDA MD 20892 NICHHD,MOL EMBRYOL LAB,NIH BETHESDA MD 20892
Titolo Testata:
EMBO journal
fascicolo: 14, volume: 16, anno: 1997,
pagine: 4361 - 4373
SICI:
0261-4189(1997)16:14<4361:RORNCO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; NUCLEOSOME ASSEMBLY INVITRO; TRANSCRIPTION IN-VIVO; HEAT-SHOCK PROMOTER; GENE-TRANSCRIPTION; SOMATIC-CELLS; CHROMATIN TEMPLATES; DNA-REPLICATION; LAEVIS OOCYTES; TBP BINDING;
Keywords:
HEAT SHOCK; MEIOSIS; NUCLEOPROTEIN; TRANSCRIPTION REPRESSION; XENOPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
N. Landsberger e A.P. Wolffe, "REMODELING OF REGULATORY NUCLEOPROTEIN COMPLEXES ON THE XENOPUS HSP70PROMOTER DURING MEIOTIC MATURATION OF THE XENOPUS OOCYTE", EMBO journal, 16(14), 1997, pp. 4361-4373

Abstract

Transcriptional repression occurs during meiotic maturation of Xenopus oocytes. Injection of a DNA template containing an hsp70 promoter into Xenopus oocytes, followed by progesterone-induced maturation has been used to demonstrate a dynamic competition between the assembly of transcription factor-containing nucleoprotein complexes and repressive nucleosomal arrays during the maturation process. In particular, it isshown that increased levels of injected heat shock protein, the transcriptional activator Gal4-VP16 or the DNA template itself all lead to reduced repression of transcription on maturation. Conversely, injection of additional histone increases repression, Repression of transcription is shown to be accompanied by the formation of a more regular array of nucleosomes and by an increase in the efficiency of nucleosome assembly on the injected plasmid. Meiotic maturation is therefore accompanied by replacement of transcription factor complexes by a repressive chromatin environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:10:59