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Titolo:
Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C
Autore:
Kang, SN; Lee, MH; Kim, KM; Cho, D; Kim, TS;
Indirizzi:
Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea Chonnam Natl Univ, Res Inst Drug Dev, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea Seoul Natl Univ, Sch Med, Canc Res Ctr, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 Ctr, Seoul 110799, South Korea
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 12, volume: 61, anno: 2001,
pagine: 1487 - 1495
SICI:
0006-2952(20010615)61:12<1487:IOHPLH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOIC ACID; INDUCED ACTIVATION; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; FLAVONOID ANTIOXIDANT; GROWTH-INHIBITION; SODIUM-BUTYRATE; MESSENGER-RNA; MILK THISTLE; SILYMARIN; EXPRESSION;
Keywords:
silibinin; HL-60 cell differentiation; 1 alpha,25-dihydroxyvitamin D-3; protein kinase C; extracellular signal-regulated kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, TS Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea ChonnamNatl Univ Kwangju South Korea 500757 500757, South Korea
Citazione:
S.N. Kang et al., "Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C", BIOCH PHARM, 61(12), 2001, pp. 1487-1495

Abstract

The effect of silibinin, an active component of Silybum marianum, on cellular differentiation was investigated in the human promyelocytic leukemia HL-60 cell culture system. Treatment of HL-60 cells with silibinin inhibited cellular proliferation and induced cellular differentiation in a dose-dependent manner. Cytofluorometric analysis and morphologic studies indicated that silibinin induced differentiation of HL-60 cells predominantly into monocytes. Importantly, strongly synergistic induction of differentiation into monocytes was observed when silibinin was combined with 5 nM 1 alpha ,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3], a well-known differentiation inducer of HL-60 cells into the monocytic lineage. Silibinin enhanced protein kinase C (PKC) activity and increased protein levels of both PKC alpha and PKC beta in 1,25-(OH)(2)D-3-treated HL-60 cells. PKC and extracellular signal-regulated kinase (ERK) inhibitors significantly inhibited HL-60 cell differentiation induced by silibinin alone or in combination with 1,25-(OH)(2)D-3, indicating that PKC and ERK may be involved in silibinin-induced HL-60 celldifferentiation. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:08:31