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Titolo:
Regulatory domain of protein stability of human P51/TAP63, a P53 homologue
Autore:
Osada, M; Inaba, R; Shinohara, H; Hagiwara, M; Nakamura, M; Ikawa, Y;
Indirizzi:
Tokyo Med & Dent Univ, Med Res Inst, Human Gene Sci Ctr, Bunkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ, Med Res Inst, Dept Retroviral Regulat, Bunkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ, Med Res Inst, Dept Funct Genom, Bunkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan RIKEN, Ikawa Lab, Wako, Saitama 3510918, Japan RIKEN Wako Saitama Japan 3510918 Ikawa Lab, Wako, Saitama 3510918, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 5, volume: 283, anno: 2001,
pagine: 1135 - 1141
SICI:
0006-291X(20010525)283:5<1135:RDOPSO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAMAGE-INDUCED PHOSPHORYLATION; DNA-DAMAGE; TRANSACTIVATION DOMAIN; MDM2; GENE; ACTIVATION; CLONING; KINASE;
Keywords:
P53 family; p51; p63; p40; p73L; KET; CUSP; protein stability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ikawa, Y Tokyo Med & Dent Univ, Med Res Inst, Human Gene Sci Ctr, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138510, Japan Tokyo Med & Dent Univ Yushima 1-5-45 Tokyo Japan 1138510 , Japan
Citazione:
M. Osada et al., "Regulatory domain of protein stability of human P51/TAP63, a P53 homologue", BIOC BIOP R, 283(5), 2001, pp. 1135-1141

Abstract

The amino terminal of human P51/TAp63, a P53 homologue, possesses a transactivation domain involved in the activation of its target genes by binding to DNA elements responsive to the p53 protein family. Using a series of amino terminal deletions, the transactivation domain was mapped between amino acid residues 50 to 69, This domain also regulates protein stability in a proteasome-dependent manner, and Ser51 and Ser68 were found to be essential for this stability. Our results suggest that P51 activity is greatly affected by protein stability. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:14:40