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Titolo:
Steroid metabolism in metabolic syndrome X
Autore:
Walker, BR;
Indirizzi:
Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Endocrinol Unit, EdinburghEH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian ScotlandEH4 2XU Midlothian, Scotland
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 1, volume: 15, anno: 2001,
pagine: 111 - 122
SICI:
1521-690X(200103)15:1<111:SMIMSX>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT MINERALOCORTICOID EXCESS; CARDIOVASCULAR RISK-FACTORS; POLYCYSTIC-OVARY-SYNDROME; LOW-BIRTH-WEIGHT; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; GLUCOCORTICOID EXPOSURE; CORTISOL SECRETION; INSULIN-RESISTANCE;
Keywords:
obesity; hypertension; diabetes mellitus; hirsutism; hydroxysteroid dehydrogenases; 5 alpha-reductase; II beta-hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, BR Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Endocrinol Unit, EdinburghEH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Scotland
Citazione:
B.R. Walker, "Steroid metabolism in metabolic syndrome X", BEST PRAC R, 15(1), 2001, pp. 111-122

Abstract

Preceding chapters in this volume describe relatively rare conditions associated with qualitative rather than quantitative changes in enzymes involved in steroid synthesis and metabolism. In this chapter, several examples show how more subtle variations in activities of the same enzymes may be important in the pathophysiology of common diseases of complex aetiology. This chapter reviews evidence for deranged steroid metabolism in patients with the 'insulin resistance syndrome'. In summary, patients with essential hypertension may have subtle 11 beta -hydroxylase or 11 beta -hydroxysteroid dehydrogenase type 2 deficiency resulting in mild mineralocorticoid excess. Patients with obesity, and/or associated hirsutism or hyperglycaemia, have evidence of altered peripheral metabolism of androgens (increased 5 alpha -reductase) and glucocorticoids (altered 11 beta -hydroxysteroid dehydrogenasetype I, resulting in enhanced cortisol levels in adipose tissue). Some of these changes in steroid metabolism lend themselves to therapeutic manipulation which may provide novel strategies to reduce cardiovascular risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:02:52