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Titolo:
NMDA receptor antagonists do not block the development of sensitization ofcatalepsy, but make its expression state-dependent
Autore:
Lanis, A; Schmidt, WJ;
Indirizzi:
Univ Tubingen, Abt Neuropharmakol, Inst Zool, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 t Zool, D-72074 Tubingen, Germany
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 143 - 149
SICI:
0955-8810(200104)12:2<143:NRADNB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL SENSITIZATION; DOPAMINE; MK-801; DIZOCILPINE; REWARD; RATS; HALOPERIDOL;
Keywords:
behavioural sensitization; D-CPPene; eliprodil; Ro 25-6981; state dependency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, WJ Univ Tubingen, Abt Neuropharmakol, Inst Zool, Mohlstr 54-1, D-72074 Tubingen, Germany Univ Tubingen Mohlstr 54-1 Tubingen Germany D-72074 , Germany
Citazione:
A. Lanis e W.J. Schmidt, "NMDA receptor antagonists do not block the development of sensitization ofcatalepsy, but make its expression state-dependent", BEHAV PHARM, 12(2), 2001, pp. 143-149

Abstract

Dopamine (DA) receptor blockade induces catalepsy in rats which increases in strength upon retesting. This increase in catalepsy represents a form ofsensitization which has been shown to be completely context dependent. Sensitization of catalepsy therefore represents a good model for studying the neurobiological mechanisms underlying the interaction between the cellular effect of a drug (I)A-receptor blockade) and the context. This study investigated whether glutamatergic mechanisms are involved in the development of sensitization. Rats were treated with either haloperidol or haloperidol plus an N-methyl-D-aspartate (NMDA) receptor antagonist. Haloperidol consistently induced catalepsy which developed sensitization upon retesting. Go-administration of D-CPPene (5 mg/kg and 10 mg/kg, i.p.), eliprodil (30 mg/kg, i.p.) or Ro 25-6981 (15 mg/kg, i.p.) did not have any effect on sensitization, although all three drugs exerted some anticataleptic effects. When sensitization developed under haloperidol plus NMDA receptor antagonist, the sensitized response was expressed only in the presence of the NMDA receptor antagonist. This strongly suggests that the NMDA receptor antagonists represent contextual stimuli to which catalepsy has been conditioned, and this implies that the expression of sensitization has been rendered state-dependent. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:00:25