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Titolo:
Effects of the NMDA receptor antagonist, D-CPPene, on sensitization to theoperant decrement produced by naloxone in morphine-treated rats
Autore:
Bespalov, AY; Medvedev, IO; Sukhotina, IA; Zvartau, EE;
Indirizzi:
Pavlov Med Univ, Valdman Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia Pavlov Med Univ St Petersburg Russia 197089 St Petersburg 197089, Russia
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 135 - 142
SICI:
0955-8810(200104)12:2<135:EOTNRA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; PRECIPITATED WITHDRAWAL; ASPARTATE; TOLERANCE; ACID; NALTREXONE; STIMULUS; MK-801; MICRODIALYSIS; PRETREATMENT;
Keywords:
naloxone; morphine; opioid withdrawal; sensitization; NMDA receptor antagonist; D-CPPene (SDZ EAA 494); operant behavior; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bespalov, AY Pavlov Med Univ, Valdman Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, 6-8 Lev Tolstoy St, St Petersburg 197089, Russia Pavlov Med Univ 6-8 Lev Tolstoy St St Petersburg Russia 197089
Citazione:
A.Y. Bespalov et al., "Effects of the NMDA receptor antagonist, D-CPPene, on sensitization to theoperant decrement produced by naloxone in morphine-treated rats", BEHAV PHARM, 12(2), 2001, pp. 135-142

Abstract

Sensitization to the rate-decreasing effects of opioid antagonists inducedby acute pretreatment with opioid agonists has been suggested to reflect initial changes in opioid systems that underlie physical dependence. Glutamate receptors are implicated in the development and expression of opioid dependence, and antagonists acting at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors have been shown repeatedly to attenuate the severityof opioid withdrawal, The present study evaluated the ability of a competitive NMDA receptor antagonist, D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid), to affect morphine-induced sensitization to naloxone in rats trained to lever-press on a multiple-trial, fixed-ratio 10 schedule of food reinforcement, D-CPPene (0.3-3 mg/kg) was administered either 4 h or 30 min prior to the test session. Morphine (10 mg/kg) orits vehicle was administered 4 h before naloxone challenge (0.3-3 mg/kg), D-CPPene failed to prevent morphine-induced potentiation of the naloxone-produced decrement in operant performance. Thus, these results suggest that agonist-induced sensitization to behavioral effects of opioid antagonists may be insensitive to NMDA receptor blockade. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 18/01/20 alle ore 07:21:24