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Titolo:
Repeated cocaine administration does not alter morphine-induced rotationalbehavior in nigrally denervated rats
Autore:
Kimmel, HL; Holtzman, SG;
Indirizzi:
Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ed, Dept Pharmacol, Atlanta, GA 30322 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 101 - 108
SICI:
0955-8810(200104)12:2<101:RCADNA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; INDUCED SENSITIZATION; CROSS-SENSITIZATION; DOPAMINE RELEASE; SUBSTANTIA-NIGRA; AMPHETAMINE; ENVIRONMENT; OPIATE; LESIONS; MODULATION;
Keywords:
cocaine; morphine; rat.; rotational behavior; sensitization; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kimmel, HL Emory Univ, Yerkes Reg Primate Res Ctr, Div Neurosci, 954 Gatewood Rd NE, Atlanta, GA 30329 USA Emory Univ 954 Gatewood Rd NE Atlanta GA USA 30329 GA 30329 USA
Citazione:
H.L. Kimmel e S.G. Holtzman, "Repeated cocaine administration does not alter morphine-induced rotationalbehavior in nigrally denervated rats", BEHAV PHARM, 12(2), 2001, pp. 101-108

Abstract

Repeated administration of morphine to rats increases their sensitivity tobehavioral effects of morphine as well as to those of psychomotor stimulants, such as cocaine and amphetamine. Conversely, stimulant-induced sensitization to behavioral effects of stimulants often results also in sensitization to behavioral effects of morphine, However, in nigrally lesioned rats, repeated injections of morphine produce sensitization to morphine-induced turning but not to turning induced by cocaine or amphetamine, The present study was performed to determine whether giving repeated cocaine injections tonigrally lesioned rats would produce cross-sensitization to morphine-induced turning. Daily injections of 10 mg/kg cocaine (i.p.) enhanced the turning response to cocaine by day 8, but not the turning response to 3.0 mg/kg morphine (s.c.). The response to morphine increased equally in both cocaine-and saline-treated animals after they had received morphine once, Dose-response curves for morphine (1.0-10 mg/kg) and for cocaine (3.0-30 mg/kg), determined during weeks 3 and 4, were the same in rats receiving daily injections of cocaine or daily injections of saline. Thus, although repeated exposure to cocaine or morphine resulted in sensitization to turning induced byeach drug, respectively, there was no cross-sensitization between the two drugs, In contrast to other behaviors, rotational behavior does not seem toexhibit cross-sensitization between morphine and psychomotor stimulants, (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 19:38:37