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Titolo:
Effects of negative punishment contingencies on cocaine self-administration by rhesus monkeys
Autore:
Nader, MA; Morgen, D;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Drug Abuse, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Ctr Neurobiol Invest Drug Abuse, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 91 - 99
SICI:
0955-8810(200104)12:2<91:EONPCO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRIC-SHOCK; REINFORCEMENT; ABSTINENCE; PHARMACOTHERAPIES; SCHEDULES; ADDICTION;
Keywords:
fixed-interval schedule; response induction; behavioral contrast; conjoint schedules of reinforcement; environmental determinants; behavioral contingencies; cocaine; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, MA Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol,Ctr Neurobiol Invest Drug Abuse, Med Ctr Blvd, Winston Salem, NC 27157 USAWake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 157 USA
Citazione:
M.A. Nader e D. Morgen, "Effects of negative punishment contingencies on cocaine self-administration by rhesus monkeys", BEHAV PHARM, 12(2), 2001, pp. 91-99

Abstract

Although punishment contingencies are widely used with human drug users, basic research on the effectiveness of these procedures is limited. The present study evaluated the effects of a negative punishment contingency, response-contingent timeout (TO) presentation, on cocaine-maintained responding. Rhesus monkeys were trained under a multiple fixed-interval (FI) 5-min cocaine, conjoint FI 5-min cocaine, variable-interval (VI) 30-sec TO schedule. TO values were either 0 (baseline), 10, 30, or 60 s in length. During the TO periods, the FI clock continued to operate but the discriminative stimuli signaling cocaine availability were removed, and responding had no scheduled consequence. Cocaine maintained responding in all monkeys and the dose-effect curve was characterized as an inverted U-shaped function. The response-contingent TO presentations reduced response rates maintained by cocainein all monkeys compared to baseline. The magnitude of the reduction in response rates was not a function of the length of the TO period (i.e. intensity of the punisher), and the punishment effect was enhanced by increases incocaine dose. When responding was punished, response rates in the unpunished components either also decreased (i.e. response induction; similar to 30% of the eases) or were not affected (similar to 60%), These results demonstrate that cocaine-maintained behavior can be decreased by environmental manipulations involving negative punishment contingencies. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 27/01/20 alle ore 07:49:51