Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The sweating apparatus in growth hormone deficiency, following treatment with r-hGH and in acromegaly
Autore:
Hasan, W; Cowen, T; Barnett, PS; Elliot, E; Coskeran, P; Bouloux, PMG;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Dept Endocrinol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 89, anno: 2001,
pagine: 100 - 109
SICI:
1566-0702(20010620)89:1-2<100:TSAIGH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; RECEPTOR MESSENGER-RNA; HUMAN SKIN; FACTOR-I; SYMPATHETIC NEURONS; NERVOUS-SYSTEM; IGF-II; INSULIN; GLANDS; LOCALIZATION;
Keywords:
growth hormone; insulin-like growth factor; adult growth hormone deficiency; acromegaly; sweating; sweat gland innervation; autonomic nerves; sympathetic nerves; vasoactive intestinal polypeptide; neuronal plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Cowen, T Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
W. Hasan et al., "The sweating apparatus in growth hormone deficiency, following treatment with r-hGH and in acromegaly", AUTON NEURO, 89(1-2), 2001, pp. 100-109

Abstract

Adult growth hormone deficient patients are known to exhibit reduced sweating and their ability to thermoregulate is diminished. Treatment of these patients with recombinant human growth hormone (r-hGH) is claimed to reversethese abnormalities. We have investigated this claim, as well as the mechanism underlying these altered sweating responses in GH-deficient patients as part of a placebo-controlled study on the effects of 6-12 months r-hGH therapy. Skin biopsies were obtained from these subjects and changes in morphology and innervation parameters for the eccrine sweat glands were examined. These included histochemistry for acetylcholinesterase (AChE) and immunohistochemistry for the neuropeptide vasoactive intestinal polypeptide (VIP) and for PGP9.5, a general neuronal marker. Sweat gland acinar size and periacinar innervation were measured by computerised image analysis. The patients underwent pilocarpine iontophoresis sweat rate tests and their serum insulin-like growth factor 1 (IGF 1) levels were assessed. Since active acromegaly involves excess GH secretion and hyperhidrosis, skin biopsies and sweat tests were also carried out on a group of these patients, as well as on control subjects. We have demonstrated a sweating defect in adult GH-deficiency which is accompanied by a reduction in AChE and VIP Levels in the nerve supply to sweatglands. Following r-hGH therapy, an increase in AChE and VIP staining is seen in the sudomotor nerves accompanied by restoration of sweat rates and serum IGF-1 levels. Hence, normalization of sweat gland function includes recovery of sudomotor synapse constituents. A trophic effect of GH on sweat gland epithelium and/or on the associated nerves is proposed, supported by the observation that in acromegaly the size of sweat gland acini and the density of innervation to the sweat glands was greater than in controls. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:14:24