Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Peripheral target contact regulates Ca2+ channels in the cell bodies of bullfrog sympathetic ganglion B-neurons
Autore:
Petrov, T; Shapiro, Y; Baker, C; Duff, JP; Sanders, EJ; Gordon, T; Smith, PA;
Indirizzi:
Univ Alberta, Div Neurosci, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 sci, Edmonton, AB T6G 2H7, Canada Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 col, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 89, anno: 2001,
pagine: 74 - 85
SICI:
1566-0702(20010620)89:1-2<74:PTCRCC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVITY FOLLOWING AXOTOMY; POTASSIUM CURRENTS; CALCIUM CURRENTS; IN-VITRO; N-TYPE; 6-HYDROXYDOPAMINE; PHOSPHORYLATION; INACTIVATION; REGENERATION; MUSCARINE;
Keywords:
nerve growth factor; neurotrophin; sympathectomy; nerve injury; neuropathic pain; axotomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, PA Univ Alberta, Div Neurosci, 9-75 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada Univ Alberta 9-75 Med Sci Bldg Edmonton AB Canada T6G 2H7 Canada
Citazione:
T. Petrov et al., "Peripheral target contact regulates Ca2+ channels in the cell bodies of bullfrog sympathetic ganglion B-neurons", AUTON NEURO, 89(1-2), 2001, pp. 74-85

Abstract

Tyrosine-hydroxyrase immunohistochemistry demonstrated that a single injection of 120 mg/kg 6-hydroxydopamine (6-OHDA) reversibly disconnected bullfrog sympathetic ganglia from their peripheral targets. This was correlated with a decrease in sympathetic outflow to the eyes and a reversible decreasein pupil diameter. 6-OHDA did not damage the cell bodies of ganglionic neurons. Calcium channel current in ganglionic B-neurons, (measured at - 10 mV; holding potential -60 mV; Ba2+ as charge carrier; I-BA) was reduced. It reached a minimum of about 40% of control amplitude 7-14 days after 6-OHDA injection and recovered to 73% of control amplitude after 63 days. 6-OHDA induced loss and recovery of functional sympathetic innervation of peripheraltarget tissues, as determined by measurement of pupil diameter, occurred at a similar rate. Thus, pupil diameter attained minimum values 7-14 days after 6-OHDA treatment and recovered to 81% of control after 63 days. The properties of Ca2+ channels in sympathetic neurons are, therefore, determined by continuity of contact with peripheral target. 6-OHDA also decreased the peak amplitude and duration of the afterhyperpolarization (a.h.p) that follows the action potential (a.p.). The rate of recovery of a.h.p duration wasmore rapid than the rate of recovery of peak a.h.p. amplitude. This may reflect known differences in properties of two types of Ca2+-sensitive K+ currents, I-C and I-AHP. I-C, which is responsible for the peak amplitude of the a.h.p has a low affinity for Ca2+, whereas I-AHP, which determines a.h.p. duration, has higher Ca2+ affinity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:36:45