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Titolo:
Distribution of cGMP in guinea pig autonomic ganglia after stimulation with sodium nitroprusside
Autore:
Holmberg, K; Steinbusch, HMW; de Vente, J; Hokfelt, T;
Indirizzi:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Maastricht Univ, EURON, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands psychol, Maastricht, Netherlands
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 89, anno: 2001,
pagine: 7 - 15
SICI:
1566-0702(20010620)89:1-2<7:DOCIGP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SUPERIOR CERVICAL-GANGLION; NADPH-DIAPHORASE ACTIVITY; LONG-TERM POTENTIATION; DORSAL-ROOT GANGLIA; CYCLIC-GMP; SPINAL-CORD; NICOTINIC TRANSMISSION; MUSCARINIC RECEPTORS; NERVOUS-SYSTEM;
Keywords:
anterior pelvic ganglion; immunohistochemistry; neuropeptides; nitric oxide synthase; tyrosine hydroxylase; sympathetic ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Holmberg, K Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 7 Stockholm, Sweden
Citazione:
K. Holmberg et al., "Distribution of cGMP in guinea pig autonomic ganglia after stimulation with sodium nitroprusside", AUTON NEURO, 89(1-2), 2001, pp. 7-15

Abstract

Nitric oxide (NO) is an intercellular messenger molecule in the nervous system and exerts its action in many regions by generating cyclic GMP (cGMP) via soluble guanylyl cyclase. In this study, on the male guinea pig, we have analyzed the localization of cGMP in some autonomic ganglia with immunohistochemistry after stimulation with sodium nitroprusside (SNP) as NO donor,and made correlations with the NO synthesizing enzyme NO synthase (NOS), tyrosine hydroxylase (TH) and some neuropeptides. The putative target neurons for NO were examined in the anterior pelvic ganglia (APGs), as well as some pre- and paravertebral sympathetic ganglia. The results show that cGMP-like immunoreactivity (LI) in the APG was in most cases observed in the TH-positive, NOS-negative neuron population, after SNP stimulation, whereas theNOS-expressing cholinergic population mostly lacked detectable cGMP-LI. Inthe pre- and paravertebral ganglia, SNP stimulation increased cGMP levels to a much lesser extent than in the APGs. cGMP was also observed in blood vessels, in the ganglion capsule, and in some cases, possibly in satellite cells. We propose, as one alternative, that there is a functional, intraganglionic regulatory loop between the parasympathetic and sympathetic divisions of the APG, using the NO/cGMP pathway. (C) 2001 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:46:01