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Titolo:
The disintegrin kistrin inhibits neurite extension from spiral ganglion explants cultured on laminin
Autore:
Aletsee, C; Mullen, L; Kim, D; Pak, K; Brors, D; Dazert, S; Ryan, AF;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Surg Otolaryngol & Neurosci, La Jolla,CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 eurosci, La Jolla,CA 92093 USA VA Med Ctr, La Jolla, CA USA VA Med Ctr La Jolla CA USAVA Med Ctr, La Jolla, CA USA Univ Wurzburg, Dept Otolaryngol Head & Neck Surg, Wurzburg, Germany Univ Wurzburg Wurzburg Germany ngol Head & Neck Surg, Wurzburg, Germany
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 57 - 65
SICI:
1420-3030(200103/04)6:2<57:TDKINE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; MICROVASCULAR ENDOTHELIAL-CELLS; NERVOUS-SYSTEM NEURONS; ADHESION MOLECULES; PERIPHERAL-NERVES; TENASCIN-C; INNER-EAR; OUTGROWTH; INTEGRIN; GLYCOPROTEIN;
Keywords:
laminin; tenascin; alpha v beta 3 integrin; kistrin; spiral ganglion; rat development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ryan, AF Univ Calif San Diego, Sch Med, Dept Surg Otolaryngol & Neurosci, 9500 Gilman Dr 0666, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr 0666 La Jolla CA USA 92093 SA
Citazione:
C. Aletsee et al., "The disintegrin kistrin inhibits neurite extension from spiral ganglion explants cultured on laminin", AUDIOL NEUR, 6(2), 2001, pp. 57-65

Abstract

The influence of laminin-1 (LN) and tenascin-C (TN), extracellular matrix molecules expressed spatially and temporally along the neural growth route from spiral ganglion (SG) neurons to the cochlear sensory cells, was evaluated in cultured SG explants from postnatal day 4 rats. Increasing concentrations of LN resulted in a strong, dose-dependent increase in the length of neurites and in a higher number of neural processes, while varying TN concentrations had relatively minor effects on both parameters. The results suggest differential receptor activation by LN and TN. When explants grown on LN were treated with Kistrin, an inhibitor of the alphav beta3 integrin, theLN-induced increase in neurite length was reduced in a dose-dependent manner. However, the number of extending neurites was not affected, indicating that different receptors mediate this response, perhaps by increasing neuronal survival, Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:03:58