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Titolo:
Family history as a risk factor for early onset myocardial infarction in young women
Autore:
Friedlander, Y; Arbogast, P; Schwartz, SM; Marcovina, SM; Austin, MA; Rosendaal, FR; Reiner, AP; Psaty, BM; Siscovick, DS;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth, Dept Social Med, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA USA Univ Washington Seattle WA USA Publ Hlth, Dept Biostat, Seattle, WA USA Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA USA Univ Washington Seattle WA USA ubl Hlth, Dept Epidemiol, Seattle, WA USA Univ Washington, Sch Publ Hlth, Dept Med, Seattle, WA USA Univ WashingtonSeattle WA USA Sch Publ Hlth, Dept Med, Seattle, WA USA Univ Washington, NW Lipid Res Labs, Seattle, WA USA Univ Washington Seattle WA USA ngton, NW Lipid Res Labs, Seattle, WA USA Univ Leiden Hosp, Dept Clin Epidemiol, Leiden, Netherlands Univ Leiden Hosp Leiden Netherlands Clin Epidemiol, Leiden, Netherlands Univ Washington, Sch Publ Hlth, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Hlth Res Unit, Seattle, WA 98195 USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 156, anno: 2001,
pagine: 201 - 207
SICI:
0021-9150(200105)156:1<201:FHAARF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; PARENTAL HISTORY; ARTERY DISEASE; DEATH; MEN; RELATIVES; GENE;
Keywords:
family history; women; myocardial infarction; early onset; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Friedlander, Y Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth, Dept Social Med, POB 12272,IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem POB 12272 Jerusalem Israel IL-91120
Citazione:
Y. Friedlander et al., "Family history as a risk factor for early onset myocardial infarction in young women", ATHEROSCLER, 156(1), 2001, pp. 201-207

Abstract

Background: The relation between a family history of heart attack and the occurrence of early myocardial infarction (MI) has not been studied extensively in women. In addition, whether recognized and newly-identified coronary heart disease (CHD) risk factors account for the familial aggregation of these events remains unknown. We therefore examined these questions in a population-based case-control study among female 18- to 44-year-old residentsof western Washington State. Methods and Results: The patients consisted of 107 women with first acute MI, and the control subjects comprised 526 women similar in age identified from the community and without a history of recognized clinical coronary heart disease or stroke. Trained interviewers used a structured questionnaire to elicit a detailed history of heart attack in first-degree relatives. Information about other known MI risk factors was collected and biochemical measurements performed, and common polymorphisms in various candidate genes were determined. The rate of MI among first-degree relatives of MI cases was twice as high as among first-degree relatives of controls (relative risk, 1.96; 95% confidence interval (CI), 1.46-2.48); this association was present for each familial relationship. Sibling history of MI but not parental history was associated with MI, after controlling for established CHD risk factors. In a subsample of subjects with blood measurements, further adjustment for lipids, lipoproteins and specific genetic risk factors slightly reduced the association with sibling MI history (from odds ratio (OR), 5.17; 95% CI, 1.93-13.85 to OR. 3.97; 95% CI, 0.92-17.17). Conclusion: Family history of MI is positively associated with the risk of early MI in women. While the association with parental history of MI is mediated through the clustering of other common risk factors, the association of sibling history of MI with early-onset MI in young women is only partially explained by the clustering of established and newly-identified risk factors. (C) 2001 Elsevier Science Ireland Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:54:50