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Titolo:
Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes
Autore:
Meguro, S; Takei, I; Murata, M; Hirose, H; Takei, N; Mitsuyoshi, Y; Ishii, K; Oguchi, S; Shinohara, J; Takeshita, E; Watanabe, K; Saruta, T;
Indirizzi:
Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 nal Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ, Sch Med, Dept Lab Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Lab Med, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 156, anno: 2001,
pagine: 151 - 156
SICI:
0021-9150(200105)156:1<151:CETPPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HIGH-DENSITY-LIPOPROTEINS; PLASMA HDL-CHOLESTEROL; CETP GENE; ATHEROSCLEROSIS; HYPERGLYCEMIA; MELLITUS; LINKAGE;
Keywords:
type 2 diabetes mellitus; atherosclerosis; cholesteryl ester transfer protein; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Meguro, S Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, 35 Shinanomachi, Tokyo1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 kyo1608582, Japan
Citazione:
S. Meguro et al., "Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes", ATHEROSCLER, 156(1), 2001, pp. 151-156

Abstract

A polymorphism in the gene for cholesteryl ester transfer protein (CETP) has been reported to be associated with serum cholesterol levels and risk for atherosclerotic vascular diseases. and to clarify the relationship between the gene polymorphism for CETP and macroangiopathy in diabetes mellitus, a cross-sectional study was performed. The subjects of the study were 182 Japanese (age: 59.6 +/- 8.6 years) with type 2 diabetes and no signs of renal dysfunction, 24 of whom had macroangiopathy, and 158 of whom did not. Thegenotype of the subjects for the TaqIB polymorphism of CETP in intron one was analyzed by using polymerase chain reaction - restriction fragment length polymorphism. Serum CETP levels were significantly higher in the B1/B1 genotype than in the other genotypes (P < 0.05). The serum CETP levels were correlated with the serum LDL cholesterol levels (P < 0.01), but not with the HDL cholesterol levels. Macroangiopathy was more frequently observed in subjects with the B1/B1 genotype than in the other genotypes (odds ratio = 2.953, 95% confidence interval = 1.250 6.977, P = 0.0136). Logistic regression analysis revealed that the CETP genotype was independently associated with macroangiopathy. The exact mechanism underlying the association remainsunknown, but differences in serum CETP levels may be involved. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:06:45