Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The distribution and production of cholesteryl ester transfer protein in the human aortic wall
Autore:
Ishikawa, Y; Ito, K; Akasaka, Y; Ishii, T; Masuda, T; Zhang, L; Akishima, Y; Kiguchi, H; Nakajima, K; Hata, Y;
Indirizzi:
Toho Univ, Sch Med, Dept Pathol, Ohtu Ku, Tokyo 1438540, Japan Toho Univ Tokyo Japan 1438540 Dept Pathol, Ohtu Ku, Tokyo 1438540, Japan Saiseikai Kanagawaken Hosp, Dept Pathol, Kanagawa Ku, Yokohama, Kanagawa 2218601, Japan Saiseikai Kanagawaken Hosp Yokohama Kanagawa Japan 2218601 2218601, Japan Kyorin Univ, Sch Med, Dept Med & Gerontol, Mitaka, Tokyo 1818611, Japan Kyorin Univ Mitaka Tokyo Japan 1818611 ntol, Mitaka, Tokyo 1818611, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 156, anno: 2001,
pagine: 29 - 37
SICI:
0021-9150(200105)156:1<29:TDAPOC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID TRANSFER PROTEIN; AMERICAN-HEART-ASSOCIATION; HIGH-DENSITY-LIPOPROTEINS; MONOCYTE-DERIVED MACROPHAGES; VASCULAR-LESIONS; TRANSGENIC MICE; ADIPOSE-TISSUE; MESSENGER-RNA; ATHEROSCLEROSIS; ARTERIOSCLEROSIS;
Keywords:
cholesteryl ester transfer protein; human aorta; smooth muscle cells; immunohistochemistry; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ishikawa, Y Toho Univ, Sch Med, Dept Pathol, Ohtu Ku, 5-21-16 Ohmori Nishi, Tokyo 1438540, Japan Toho Univ 5-21-16 Ohmori Nishi Tokyo Japan 1438540 540, Japan
Citazione:
Y. Ishikawa et al., "The distribution and production of cholesteryl ester transfer protein in the human aortic wall", ATHEROSCLER, 156(1), 2001, pp. 29-37

Abstract

Cholesteryl ester transfer protein (CETP) has been considered to mediate the transfer of cholesteryl ester from arterial wall, however, the distribution and production of CETP in human arterial wall remains unclear. Present study histopathologically demonstrated the distribution of CETP and CETP mRNA in thr human aortic wall by immunohistochemistry and in situ hybridization. While CETP was constantly distributed in the media, the protein was recognized within the intima with fibrocellular thickening and atheroscleroticintima. Double immunostaining methods demonstrated CETP expression in smooth muscle cells in the intima and media. CETP mRNA was detected not only inintimal cells but medial smooth muscle cells. Intimal cells expressing CETP mRNA were considered to be monocyte-derived macrophages and smooth musclecells by immunohistochemistries using two antibodies against smooth muscleactin and human macrophage on the subserial sections. Our in vivo study provides that CETP is produced by smooth muscle cells in the intima and mediaof human aorta, and it is suggested that arterial smooth muscle cells positively participate in the removal of excessive cholesteryl ester from the arterial wall by CETP production. (C) 2001 Elsevier Science Ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 17:53:18