Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays
Autore:
Feron, VJ; Kittel, B; Kuper, CF; Ernst, H; Rittinghausen, S; Muhle, H; Koch, W; Gamer, A; Mallett, AK; Hoffmann, HD;
Indirizzi:
TNO, Div Toxicol, NL-3700 AJ Zeist, Netherlands TNO Zeist Netherlands NL-3700 AJ Toxicol, NL-3700 AJ Zeist, Netherlands BASF Aktiengesell, Dept Toxicol, D-67056 Ludwigshafen, Germany BASF Aktiengesell Ludwigshafen Germany D-67056 056 Ludwigshafen, Germany Fraunhofer Inst Toxikol & Aerosolforsch, D-30625 Hannover, Germany Fraunhofer Inst Toxikol & Aerosolforsch Hannover Germany D-30625 Germany Shell Chem, CEAS Shell Ctr, London SE1 7NA, England Shell Chem London England SE1 7NA EAS Shell Ctr, London SE1 7NA, England
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 159 - 175
SICI:
0340-5761(200105)75:3<159:CPEORM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
4,4'-METHYLENEDIPHENYL DIISOCYANATE; INHALATION TOXICITY; WISTAR RATS; EXPOSURE; ADDUCTS;
Keywords:
methylene diphenyl diisocyanate (MDI); inhalation; combined long-term rat bioassays; pulmonary effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Feron, VJ TNO, Div Toxicol, POB 360, NL-3700 AJ Zeist, Netherlands TNO POB360 Zeist Netherlands NL-3700 AJ AJ Zeist, Netherlands
Citazione:
V.J. Feron et al., "Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays", ARCH TOXIC, 75(3), 2001, pp. 159-175

Abstract

Two independent bioassays are available which have examined the potential carcinogenicity of monomeric and polymeric methylene diphenyl diisocyanate (MDI) following long-term inhalation exposure in rats. These studies are not directly comparable, however, due to differences in design and conduct ofthe in-life phase, and differences in nomenclature used for some of the histopathological findings. This paper presents a definitive overview of the pulmonary toxicity of MDI developed following a thorough review of both investigations. As part of this process, the test materials and the designs ofthe studies were compared, and an in-depth review of lung lesions was conducted by an independent reviewing pathologist. This included the reexamination of the original lung slides, supported by an analysis of the exposure regimens, the results of which were used to develop an accurate profile of the doses received by the animals in the two studies. Histopathological findings were then combined with this information to give an overall dose-response curve for both studies as a whole. The range of total inhalation exposures to MDI was calculated as 559, 1972, 2881, 6001, 17,575 and 17,728 mgh/m(3). Major pulmonary effects included increased lung weights together with bronchiolo-alveolar adenomas and hyperplasia, and interstitial fibrosis which occurred consistently in both studies, indicating a very similar qualitative response of the lungs to polymeric and monomeric MDI. The quantitativeresponse of the lung was clearly dose-related in each study, and when the studies were considered as a whole a reasonable overall dose-response relationship was apparent for major lung lesions. Lung tumours tin low incidences) only occurred at the highest dose level in both studies (17,575 and 17,728 mgh/m(3)). For inflammatory and other non-neoplastic pulmonary changes, the lowest dose examined (559 mgh/m(3)) was regarded as a no-observed-adverse-effect-level for both polymeric and monomeric MDI. It was concluded thatthe results of the two studies could be combined to serve as a basis for human risk assessment of MDI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:53:19