Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An immunostaining panel for diagnosis of malignancy in mucinous tumors of the pancreas
Autore:
Zhao, J; Liang, SX; Savas, L; Banner, BF;
Indirizzi:
UMASS Mem Hlth Care, Dept Pathol, Worcester, MA USA UMASS Mem Hlth Care Worcester MA USA are, Dept Pathol, Worcester, MA USA
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 6, volume: 125, anno: 2001,
pagine: 765 - 769
SICI:
0003-9985(200106)125:6<765:AIPFDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SUPPRESSOR GENE; HER-2/NEU EXPRESSION; IMMUNOHISTOCHEMICAL EVALUATION; FACTOR RECEPTOR; P53; CANCER; ADENOCARCINOMA; C-ERBB-2; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Banner, BF UMASS Univ Hosp Ctr, Dept Pathol, 55 Lake Ave N, Worcester, MA 01655 USA UMASS Univ Hosp Ctr 55 Lake Ave N Worcester MA USA 01655 55 USA
Citazione:
J. Zhao et al., "An immunostaining panel for diagnosis of malignancy in mucinous tumors of the pancreas", ARCH PATH L, 125(6), 2001, pp. 765-769

Abstract

Background - The diagnosis of malignancy in pancreatic mucinous cystic tumors depends on demonstrating invasion that may be focal and require extensive sectioning. Objective - To explore markers that may indicate malignant potential in mucinous cystic tumors. Design - Routinely processed sections from resected specimens of 12 normalpancreata, 14 pancreata with chronic pancreatitis, 9 mucinous cystic tumors, and 30 invasive adenocarcinomas were immunostained with antibodies to p53, HER-2/neu, epithelial growth factor receptor (ECFR), transforming growthfactor alpha (TCF-alpha), and Ki-67. Results - Expression of p53, HER-2/neu, and Ki-67 was significantly more frequent in mucinous tumors than in normal pancreatic tissue and chronic pancreatitis tissue (P = .0003 to .05). Strong expression (more than one thirdof cells positive) and strong intensity (2+ and 3+) of staining of p53 andECFR were seen only in carcinomas. Coexpression of p53/HER-2/neu and EGFR/HER-2/neu and a frequency of Ki-67+ nuclei of greater than 5% of cells discriminated between mucinous tumors and normal pancreatic tissue and chronic pancreatitis tissue. p53 expression was significantly more frequent in carcinomas than in mucinous tumor (P = .0326). Coexpression of p53/EGFR discriminated between mucinous tumors and carcinomas; however, TCF-alpha was not discriminative. Conclusions - The immunostaining panel of p53, HER2/neu, Ki-67, and EGFR can be helpful in indicating malignant potential in mucinous tumors of pancreas in routine pathology practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:55:12