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Titolo:
Increasing drug concentration in a rat lung tumor model by combining isolated lung perfusion with hypertensive chemotherapy
Autore:
Matsuoka, T; Kaneda, Y; Li, TS; Tanaka, T; Zempo, N; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 21, anno: 2001,
pagine: 1219 - 1223
SICI:
0250-7005(200103/04)21:2A<1219:IDCIAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY METASTASES; BLOOD-FLOW; ANGIOTENSIN-II; SARCOMA; DOXORUBICIN; CISPLATIN; MELPHALAN; SURVIVAL; INFUSION; CANCER;
Keywords:
isolated lung perlusion; endothelin; induced-hypertensive chemotherapy; cisplatin; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuoka, T Yamaguchi Univ, Sch Med, Dept Surg 1, Minami Kogushi 1-1-1, Ube, Yamaguchi7558505, Japan Yamaguchi Univ Minami Kogushi 1-1-1 Ube Yamaguchi Japan 7558505
Citazione:
T. Matsuoka et al., "Increasing drug concentration in a rat lung tumor model by combining isolated lung perfusion with hypertensive chemotherapy", ANTICANC R, 21(2A), 2001, pp. 1219-1223

Abstract

Isolated left lung perfusion (ILP) with cisplatin was performed in Fisher 344 rats. Before perfusion, bolus injection with endothelin was given via the pulmonary artery. The vasoconstrictive potency was estimated by monitoring the perfusion pressure. The toxicity was estimated by tracking body weight change, survival rate after right pneumonectomy, arterial blood gas analysis and histological findings. To observe the pharmacokinetic changes, a solitary Methylcholanthrene-induced sarcoma model was established in a rat lung and the total platinum concentration in perfused lung and tumor tissueswas measured. perfusion pressure was increased significantly in a dose-dependent manner. Pulmonary toxicity from ILP with cisplatin was limited by the use of endothelin. Significantly higher levels of total platinum were obtained in tumors but not in normal lung tissues by endothelin injection before ILP than by ILP alone. The combination of ILP and hypertensive chemotherapy should be one of the available treatments for unresectable pulmonary carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:49:11