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Titolo:
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study
Autore:
Malusecka, E; Zborek, A; Krzyzowska-Gruca, S; Krawczyk, Z;
Indirizzi:
Maria Sklodowska Curie Mem Inst, Ctr Oncol, Dept Cytochem & Cell Ultrastruct, PL-44100 Gliwice, Poland Maria Sklodowska Curie Mem Inst Gliwice Poland PL-44100 Gliwice, Poland Maria Sklodowska Curie Mem Inst, Ctr Oncol, Dept Tumor Biol, PL-44100 Gliwice, Poland Maria Sklodowska Curie Mem Inst Gliwice Poland PL-44100 Gliwice, Poland
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 21, anno: 2001,
pagine: 1015 - 1021
SICI:
0250-7005(200103/04)21:2A<1015:EOHSPH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROID-RECEPTOR STATUS; BREAST-CANCER; P53 PROTEIN; PROGNOSTIC-SIGNIFICANCE; RESISTANCE PROTEINS; DRUG-RESISTANCE; CYCLIN D1; HEAT-SHOCK-PROTEIN-70; ADENOCARCINOMAS; OVEREXPRESSION;
Keywords:
HSP/C70; HSP27; immunohistochemistry; lung carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Malusecka, E Maria Sklodowska Curie Mem Inst, Ctr Oncol, Dept Cytochem & Cell Ultrastruct, Wybrzeze Armii Krajowej 15, PL-44100 Gliwice, Poland MariaSklodowska Curie Mem Inst Wybrzeze Armii Krajowej 15 Gliwice Poland PL-44100
Citazione:
E. Malusecka et al., "Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study", ANTICANC R, 21(2A), 2001, pp. 1015-1021

Abstract

The present study was undertaken to determine the expression pattern of the hsp70 and the hsp27genes in 106 cases of non-small cell lung carcinoma (NSCLC). We have shown that in the majority of cases (95/106) the HSP70 immunoreactivity was localized both in the cytoplasm and the nuclei. We also observed an enhanced nuclear immunoreaction for HSP70 in dysplastic lesions and in stage I tumors. In the case of the HSP27 we found a positive cytoplasmic immunostaining in 70% of cases, with the highest score in squamous cell carcinoma (SCC). We noted a positive correlation between the expression level of HSP27 and HSP70. There was a correlation between Ki-67 proliferation index and nuclear HSP70 staining, but not for HSP27. No association betweenthe HSPs and the. expression of pRb p16 and p21(WAF1/CP1) and p53 was found as studied previously. An interesting and statistically significant relationship was found between the expression of cyclin DI and high intensity ofHSP27 and HSP70 immunostaining. The relation of our results concerning theexpression pattern of the HSP70 and HSP27 in NSCLC to those obtained by others for different types of primary tumors is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:22:50