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Titolo:
Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy
Autore:
Lin, JY; Page, C; Jin, XH; Sethi, AO; Patel, R; Nunez, G;
Indirizzi:
Univ Michigan, Ctr Comprehens Canc, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t & Gynecol, Ann Arbor, MI 48109 USA Univ Michigan, Ctr Comprehens Canc, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 21, anno: 2001,
pagine: 831 - 839
SICI:
0250-7005(200103/04)21:2A<831:SAOPGP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTHERAPY-INDUCED APOPTOSIS; BCL-X-L; WILD-TYPE P53; PROSTATE-CANCER; CYTOCHROME-C; OVARIAN-CANCER; ACTIVATES APOPTOSIS; CASPASE ACTIVATION; BREAST-CANCER; DEATH AGONIST;
Keywords:
pro-apoptotic genes; Bcl-2; Bcl-X-L; gene therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, JY Univ Michigan, Ctr Comprehens Canc, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 col, Ann Arbor, MI 48109 USA
Citazione:
J.Y. Lin et al., "Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy", ANTICANC R, 21(2A), 2001, pp. 831-839

Abstract

Overexpression of anti-apoptotic Bcl-2 and Bcl-X-L proteins may play a role in the development of resistance to cancer therapy. We examined the expression of these proteins in prostate, breast, and ovarian cancer cells. We found that some of these cancer cell lines expressed high levels of Bcl-X-L or Bcl-2., In order to develop an effective strategy to overcome the potential inhibition of cancer therapy by Bcl-2 and Bcl-X-L, we tested the inhibitory ability of several pro-apoptotic or tumor suppressor genes in these cells. The expression of these genes induced apoptosis or suppressed cell growth with variable efficiency in these cells. Harakiri (Hrk) appears to result in the greatest induction of apoptosis or inhibition of cell growth. Mtd, bar and bcl-X-S were also effective in inhibiting cell growth. Furthermore e, transfection of Hrk, bar, or Mtd into these cells caused significantlyless colony formation than in cells transfected with p53 or BRCA1. Therefore, these results suggest that Hrk, bas and Mtd are potent therapeutic agents for cancers expressing high levels of Bcl-2 and Bcl-X-L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:46:16