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Titolo:
Prostate-specific antigen density adjusted for the transition zone for staging clinically localized prostate cancer in Japanese patients with intermediate serum prostate-specific antigen levels
Autore:
Furuya, Y; Ohta, S; Sato, N; Kotake, T; Sugano, I; Nagao, K; Masai, M;
Indirizzi:
Teikyo Univ, Sch Med, Ichihara Hosp, Dept Urol, Chiba 2990111, Japan Teikyo Univ Chiba Japan 2990111 ra Hosp, Dept Urol, Chiba 2990111, Japan Teikyo Univ, Sch Med, Ichihara Hosp, Dept Pathol, Chiba 2990111, Japan Teikyo Univ Chiba Japan 2990111 Hosp, Dept Pathol, Chiba 2990111, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2B, volume: 21, anno: 2001,
pagine: 1317 - 1320
SICI:
0250-7005(200103/04)21:2B<1317:PADAFT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADICAL RETROPUBIC PROSTATECTOMY; PATHOLOGICAL STAGE; PREDICTIVE VALUE; ADENOCARCINOMA; CARCINOMA; VOLUME; PSA;
Keywords:
prostate cancer; prostate-specific antigen; transition zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Furuya, Y Teikyo Univ, Sch Med, Ichihara Hosp, Dept Urol, Anesaki 3426-3, Chiba 2990111, Japan Teikyo Univ Anesaki 3426-3 Chiba Japan 2990111 a 2990111, Japan
Citazione:
Y. Furuya et al., "Prostate-specific antigen density adjusted for the transition zone for staging clinically localized prostate cancer in Japanese patients with intermediate serum prostate-specific antigen levels", ANTICANC R, 21(2B), 2001, pp. 1317-1320

Abstract

The prostate-specific antigen (PSA) density of the transition zone (PSATZ)in 45 prostate cancer patients who received radical prosratectomy with a PSA value of 4.1 - 10 ng/ml was determined to see whether PSATZ was useful in the prediction of extracapsular invasion of prostate cancer. The value ofPSATZ for the detection of extracapsular invasion was compared with that of PSA and PSA density (PSAD). Thirty-one patients (68.9%) had pathologically organ confined cancer while 14 (31.1%) had extracapsular disease. Patients with organ confined tumor had significantly lower PSAD and PSATZ than those with non-organ confined rumor. PSATZ was superior to PSA when analyzed by receiver operating characteristics curves. In those patients with a cut-off value of 1.0 ng/ml per ml of transition zone volume, the PSATZ had a sensitivity of 43% and a specificity of 90% for prediction of extracapsular extension. The present study demonstrated that PSATZ was superior to PSA as apredictor of extracapsular invasion in intermediate PSA levels. Measurement of PSATZ may be of additional value to indicate the need for radical prostatectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:37:26