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Titolo:
L-arginine in the management of cardiovascular diseases
Autore:
Cheng, JWM; Balwin, SN;
Indirizzi:
Long Isl Univ, Arnold & Marie Schwartz Coll Pharm & Hlth Sci, Brooklyn, NY11201 USA Long Isl Univ Brooklyn NY USA 11201 arm & Hlth Sci, Brooklyn, NY11201 USA Mt Sinai Med Ctr, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA10029 ai Med Ctr, New York, NY 10029 USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 6, volume: 35, anno: 2001,
pagine: 755 - 764
SICI:
1060-0280(200106)35:6<755:LITMOC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL L-ARGININE; CORONARY-ARTERY DISEASE; DIETARY L-ARGININE; ENDOTHELIUM-DEPENDENT VASODILATION; CONGESTIVE-HEART-FAILURE; CHOLESTEROL-FED RABBITS; NITRIC-OXIDE RELEASE; DOUBLE-BLIND; HYPERCHOLESTEROLEMIC RABBITS; NO PRODUCTION;
Keywords:
L-arginine; cardiovascular diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Cheng, JWM Long Isl Univ, Arnold & Marie Schwartz Coll Pharm & Hlth Sci, 75 DeKalb Ave, Brooklyn, NY 11201 USA Long Isl Univ 75 DeKalb Ave Brooklyn NY USA 11201 NY 11201 USA
Citazione:
J.W.M. Cheng e S.N. Balwin, "L-arginine in the management of cardiovascular diseases", ANN PHARMAC, 35(6), 2001, pp. 755-764

Abstract

OBJECTIVE: TO examine the role of L-arginine in the management of cardiovascular diseases. DATA SOURCES: A MEDLINE search (1966-April 2000) of review articles, usingthe search terms arginine, nitric oxide, and cardiovascular diseases, was conducted. After reviewing these articles, primary studies using the searchterms arginine, hypercholesterolemia, hypertension, diabetes, smoking, ischemic heart disease, and heart failure were reviewed. STUDY SELECTION: English-language human studies were selected and evaluated based on quality of review. DATA SYNTHESIS: Small-scale studies have demonstrated that intravenous L-arginine augments endothelial function by enhancing vasodilation and reducing monocyte adhesion. Oral supplementation demonstrated similar effects as well as improvement of exercise ability in patients with cardiovascular diseases. CONCLUSIONS: L-arginine improves the management of multiple cardiovasculardiseases. However, most published human studies are small. Before therapy can be routinely recommended, larger, well-designed studies are required toconfirm its effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:00:54