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Titolo:
Proton-pump inhibitors for acute peptic ulcer bleeding
Autore:
Erstad, BL;
Indirizzi:
Coll Pharm, Dept Pharm Practice & Sci, Tucson, AZ 85721 USA Coll Pharm Tucson AZ USA 85721 Pharm Practice & Sci, Tucson, AZ 85721 USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 6, volume: 35, anno: 2001,
pagine: 730 - 740
SICI:
1060-0280(200106)35:6<730:PIFAPU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; UPPER GASTROINTESTINAL HEMORRHAGE; SUCCESSFUL ENDOSCOPIC THERAPY; RANDOMIZED COMPARATIVE TRIAL; NONBLEEDING VISIBLE VESSEL; NATIONAL ASGE SURVEY; INTRAVENOUS OMEPRAZOLE; HELICOBACTER-PYLORI; INJECTION THERAPY; RANITIDINE;
Keywords:
omeprazole; peptic ulcer; proton pump inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Erstad, BL Coll Pharm, Dept Pharm Practice & Sci, 1703 E Mabel St, Tucson,AZ 85721 USA Coll Pharm 1703 E Mabel St Tucson AZ USA 85721 on, AZ 85721 USA
Citazione:
B.L. Erstad, "Proton-pump inhibitors for acute peptic ulcer bleeding", ANN PHARMAC, 35(6), 2001, pp. 730-740

Abstract

OBJECTIVE: TO review the use of proton-pump inhibitors for acute peptic ulcer bleeding. DATA SOURCES: Articles were obtained through computerized searches of MEDLINE (1966-September 2000). Additionally, several textbooks containing information on the diagnosis and management of acute peptic ulcer bleeding were reviewed. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELECTION: All randomized studies and pharmacoeconomic evaluations that used proton-pump inhibitor therapy for acute peptic ulcer bleeding wereincluded. Randomized controlled trials and meta-analyses involving other therapies for treating peptic ulcer bleeding were also reviewed for possibleinclusion. DATA EXTRACTION: The primary outcomes extracted from the literature were persistent or recurrent bleeding, transfusion requirements, need for endoscopic intervention or surgery, length of stay, and mortality. DATA SYNTHESIS: Data from double-blind, placebo-controlled trials involving more than 1000 patients demonstrate that short-term, high-dose omeprazoletherapy is effective for reducing bleeding and transfusion requirements inpatients with acute peptic ulcer bleeding. The patients most likely to benefit from this therapy are hospitalized patients at high risk for rebleeding and patients in whom endoscopic evaluation must be delayed or is unavailable. CONCLUSIONS: Omeprazole land likely other proton-pump inhibitors) is useful in reducing bleeding and transfusion requirements in patients with acute peptic ulcer bleeding, although better delineation of appropriate candidates is needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:14:08