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Titolo:
Lithium-related genetics of bipolar disorder
Autore:
Detera-Wadleigh, SD;
Indirizzi:
NIMH, Intramural Res Program, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 mural Res Program, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 4, volume: 33, anno: 2001,
pagine: 272 - 285
SICI:
0785-3890(200105)33:4<272:LGOBD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOGEN-SYNTHASE KINASE-3; MANIC-DEPRESSIVE ILLNESS; INOSITOL POLYPHOSPHATE 1-PHOSPHATASE; MYOINOSITOL MONOPHOSPHATASE GENE; MAGNETIC-RESONANCE SPECTROSCOPY; RESPONSIVE AFFECTIVE-DISORDERS; LONG-TERM LITHIUM; GENOMIC STRUCTURE; FAMILY HISTORY; MOOD DISORDERS;
Keywords:
Akt; association; expression profiling; glycogen synthase kinase-3 beta; IMPA2; linkage; protein kinase C; single-nucleotide polymorphisms; susceptibility; Wnt;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Detera-Wadleigh, SD NIMH, Intramural Res Program, NIH, Bldg 36 Room 3D16, Bethesda, MD 20892 USA NIMH Bldg 36 Room 3D16 Bethesda MD USA 20892 20892 USA
Citazione:
S.D. Detera-Wadleigh, "Lithium-related genetics of bipolar disorder", ANN MED, 33(4), 2001, pp. 272-285

Abstract

Lithium is a potent prophylactic medication and mood stabilizer in bipolardisorder. However, clinical outcome is variable. and its therapeutic effect manifests after a period of chronic treatment, implying a progressive andcomplex biological response process, Signal transduction systems known to be perturbed by lithium involve phosphoinositide (PI) turnover, activation of the Wnt pathway via inhibition of glycogen synthase kinase-3 beta (GSK-3beta), and a growth factor-induced, Akt-mediated signalling that promotes cell survival. These pathways, acting in synergy. probably prompt the amplification of lithium signal causing such immense impact on the neuronal network. The sequencing of the human genome presents an unparallelled opportunity to uncover the full molecular repertoire involved in lithium action. Interrogation of high-resolution expression micro-arrays and protein profiles represents a strategy that should help accomplish this goal. A recent microarray analysis on lithium-treated versus untreated PC12 cells identified multiple differentially altered transcripts. Lithium-perturbed genes, particularly those that map to susceptibility regions, could be candidate risk-conferring factors for mood disorders. Transcript and protein profiling in patients could reveal a lithium fingerprint for responsiveness or nonresponsiveness, and a signature motif that may be diagnostic of a specific phenotype. Similarly, lithium-sensitive gene products could provide a new generationof pharmacological targets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:13:11