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Titolo:
Candidate gene studies of bipolar disorder
Autore:
Jones, I; Craddock, N;
Indirizzi:
Univ Birmingham, Div Neurosci, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 4, volume: 33, anno: 2001,
pagine: 248 - 256
SICI:
0785-3890(200105)33:4<248:CGSOBD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; MONOAMINE-OXIDASE-A; O-METHYLTRANSFERASE GENE; LOW-ACTIVITY ALLELE; MANIC-DEPRESSIVE ILLNESS; DEPENDENT DIABETES-MELLITUS; COMPLEX HUMAN-DISEASES; LINKAGE-DISEQUILIBRIUM; TYROSINE-HYDROXYLASE; ASSOCIATION ANALYSIS;
Keywords:
association study; bipolar disorder; genetics; manic depression; mood disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Craddock, N Univ Birmingham, Queen Elizabeth Psychiat Hosp, Div Neurosci, Birmingham B15 2QZ, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2QZ England
Citazione:
I. Jones e N. Craddock, "Candidate gene studies of bipolar disorder", ANN MED, 33(4), 2001, pp. 248-256

Abstract

Genetic factors undoubtedly play an important role in determining vulnerability to bipolar disorder but the task of finding susceptibility genes is not trivial. Candidate gene studies, usually employing the association approach, offer the potential to discover the genes of relatively modest effect size that are expected for a complex genetic disorder. Candidate gene approaches depend crucially on our current understanding of disease pathophysiology, and attention has consequently been focussed on a limited range of neurotransmitter systems implicated by the action of drug treatments. Despite no unequivocal. consistently replicated findings, a number of intriguing results have emerged in the literature, both for bipolar disorder in general and for subtypes such as bipolar affective puerperal psychosis and rapid cycling bipolar illness. Genes of particular current interest include those encoding the serotonin transporter. monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). As susceptibility genes are found and knowledge of aetiology advanced it is likely that many more candidate genes in novel biological systems will attract attention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:30:56