Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Stepwise regression analysis to study male and female factors impacting onpregnancy rate in an intrauterine insemination programme
Autore:
Gauci, MM; Kruger, TF; Coetzee, K; Smith, K; van der Merwe, JP; Lombard, CJ;
Indirizzi:
Tygerberg Hosp, Reprod Biol Unit, ZA-7505 Tygerberg, South Africa Tygerberg Hosp Tygerberg South Africa ZA-7505 05 Tygerberg, South Africa Univ Stellenbosch, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa MRC, CERSA, Div Epidemiol & Biostat, Tygerberg, South Africa MRC Tygerberg South Africa Epidemiol & Biostat, Tygerberg, South Africa
Titolo Testata:
ANDROLOGIA
fascicolo: 3, volume: 33, anno: 2001,
pagine: 135 - 141
SICI:
0303-4569(200105)33:3<135:SRATSM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED OVARIAN HYPERSTIMULATION; HUMAN MENOPAUSAL GONADOTROPIN; ABNORMAL SPERM MORPHOLOGY; IN-VITRO FERTILIZATION; STRICT CRITERIA; INVITRO FERTILIZATION; CLOMIPHENE CITRATE; PROGNOSTIC FACTOR; CYCLE FECUNDITY; INFERTILITY;
Keywords:
female factor; intrauterine insemination; idiopathic infertility; male factor; sperm morphology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kruger, TF Tygerberg Hosp, Reprod Biol Unit, POB 19058, ZA-7505 Tygerberg,South Africa Tygerberg Hosp POB 19058 Tygerberg South Africa ZA-7505 Africa
Citazione:
M.M. Gauci et al., "Stepwise regression analysis to study male and female factors impacting onpregnancy rate in an intrauterine insemination programme", ANDROLOGIA, 33(3), 2001, pp. 135-141

Abstract

The aim of this study was to evaluate the impact of male and female factors on the pregnancy rate in an intrauterine insemination (IUI) programme. Data on 522 cycles were retrospectively studied. All patients 39 years or younger were included in the study where data were available on male and female diagnosis, as well as on ovulation induction methodology. Regression analysis was possible on 495 cycles to study different factors affecting the pregnancy rate per treatment cycle. Logistic regression identified variables which were related to outcome and were subsequently incorporated into a statistical model. The number of follicles was found to have a linear association with the risk ratio (chance) of pregnancy. The age of the woman was also found to have a linear (negative) association with pregnancy. The percentage motility and percentage normal morphology (by strict criteria) of spermatozoa in the fresh ejaculate were the male factors that significantly and independently predicted the outcome. Percentage motility 250 was associatedwith a risk ratio of pregnancy of 2.95 compared to percentage motility < 50. Percentage normal sperm morphology > 14% was associated with a risk ratio of pregnancy of 1.8 compared to percentage normal morphology less than orequal to 14%. Female patients with idiopathic infertility were divided into three groups according to normal sperm morphology. The pregnancy rate percycle was 2.63% (1/38) for the P (poor) pattern group (0-4 % normal forms), 11.4 % (17/119) for the G (good) pattern group (5-14%), and 24% (18/75) for the N (normal) pattern group (> 14% normal forms). A female diagnosis ofendometriosis or tubal factor impacted negatively on the probability of pregnancy (risk ratio of 0.17), compared with other female diagnoses. Male and female factors contribute to pregnancy outcome, but the clinician can influence prognosis by increasing the number of follicles, especially in severe male factor cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:51:13