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Titolo:
Haploid spermatids exhibit translationally repressed mRNAs
Autore:
Steger, K;
Indirizzi:
Inst Vet Anat, D-35392 Giessen, Germany Inst Vet Anat Giessen Germany D-35392 Vet Anat, D-35392 Giessen, Germany
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 5, volume: 203, anno: 2001,
pagine: 323 - 334
SICI:
0340-2061(200105)203:5<323:HSETRM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-BINDING-PROTEIN; 3' UNTRANSLATED REGION; MALE GERM-CELLS; HUMAN MALE-INFERTILITY; Y-BOX PROTEINS; MESSENGER-RIBONUCLEOPROTEIN PARTICLES; RESPONSIVE ELEMENT MODULATOR; MAJOR CHROMOSOMAL PROTEIN; BASIC NUCLEAR PROTEINS; GENE-EXPRESSION;
Keywords:
male infertility; nucleoproteins; RNA-binding proteins; spermiogenesis; translational regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
132
Recensione:
Indirizzi per estratti:
Indirizzo: Steger, K Inst Vet Anat, Frankfurter Str 98, D-35392 Giessen, Germany InstVet Anat Frankfurter Str 98 Giessen Germany D-35392 ermany
Citazione:
K. Steger, "Haploid spermatids exhibit translationally repressed mRNAs", ANAT EMBRYO, 203(5), 2001, pp. 323-334

Abstract

During spermiogenesis, DNA-binding histones are replaced by protamines. DNA-protamine-interactions result in chromatin condensation causing cessationof transcription in elongating spermatids. Thus, in haploid spermatids, processes of transcription and translation need to be temporally uncoupled inorder to ensure protein synthesis in transcriptionally silent germ cells. Posttranscriptional events, such as processing, transport, and storage of mRNAs, therefore, play important roles in determining when transcripts become functionally available for translation. This review focuses on mechanismsof translational regulation in haploid spermatids and male infertility caused by defects of translational control processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:28:56