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Titolo:
Neuroleptic malignant syndrome after haloperidol application
Autore:
Gerbershagen, MU; Ito, WD; Wappler, F; Fiege, M; Esch, JSA;
Indirizzi:
Univ Hamburg, Hosp Eppendorf, Klin & Poliklin Anasthesiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 asthesiol, D-20246 Hamburg, Germany Univ Hamburg, Hosp Eppendorf, Med Klin 2, Abt Kardiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 t Kardiol, D-20246 Hamburg, Germany
Titolo Testata:
ANAESTHESIST
fascicolo: 5, volume: 50, anno: 2001,
pagine: 329 - 332
SICI:
0003-2417(200105)50:5<329:NMSAHA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
THERAPY;
Keywords:
neuroleptic malignant syndrome; haloperidol; hyperthermia; creatine phosphokinase; muscle rigidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Gerbershagen, MU Univ Hamburg, Hosp Eppendorf, Anasthesiol Klin, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 rmany
Citazione:
M.U. Gerbershagen et al., "Neuroleptic malignant syndrome after haloperidol application", ANAESTHESIS, 50(5), 2001, pp. 329-332

Abstract

The neuroleptic malignant syndrome (NMS) is a rare complication of antipsychotic therapy. We report on a 65-year-old patient who was treated with haloperidol, diazepam and mirtazapin because of a severe depressive episode with psychotic symptoms. He exhibited most of the signs and symptoms characteristic of NMS, e.g.: hyperthermia, rigidity, elevated creatine phosphokinase, eukocytosis, elevated liver enzymes, reduced consciousness and autonomicnervous system disturbances. A secondary pneumonia was diagnosed 2 days after the onset of the NMS, which might have been due to chest wall rigidity. Intensive care treatment consisted of immediate discontinuation of the offending agent, supportive therapy with rehydratation and catecholamines as well as application of dantrolen. After 23 days of intensive therapy all pathological parameters were normalised and the patient was transferred to an internal ward. Three main theories on the pathogenesis of NMS exist: 1.blockade of central receptors, 2. a skeletal muscle target model and 3. sympathoadrenal hyperactivity. The differential diagnosis includes among others malignant hyperthermia and serotonin syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:24:58