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Titolo:
Proteomic comparison of human and great ape blood plasma reveals conservedglycosylation and differences in thyroid hormone metabolism
Autore:
Gagneux, P; Amess, B; Diaz, S; Moore, S; Patel, T; Dillmann, W; Parekh, R; Varki, A;
Indirizzi:
Univ Calif San Diego, Glycobiol & Training Ctr, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ng Ctr, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA Oxford Glycosci, Abingdon, Oxon, England Oxford Glycosci Abingdon Oxon England Glycosci, Abingdon, Oxon, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
fascicolo: 2, volume: 115, anno: 2001,
pagine: 99 - 109
SICI:
0002-9483(200106)115:2<99:PCOHAG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; N-GLYCOLYLNEURAMINIC ACID; HAPTOGLOBIN GENE-CLUSTER; RETINOL-BINDING PROTEIN; MOLECULAR PHYLOGENY; TRANSPORT PROTEINS; HUMAN-EVOLUTION; CHIMPANZEE; DNA; SEQUENCE;
Keywords:
great apes; proteomics; transthyretin; thyroid hormone; glycosylation; evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Varki, A Univ Calif San Diego, Glycobiol & Training Ctr, 0687, La Jolla, CA 92093 USA Univ Calif San Diego 0687 La Jolla CA USA 92093 lla, CA 92093 USA
Citazione:
P. Gagneux et al., "Proteomic comparison of human and great ape blood plasma reveals conservedglycosylation and differences in thyroid hormone metabolism", AM J P ANTH, 115(2), 2001, pp. 99-109

Abstract

Most blood plasma proteins are glycosylated. These glycoproteins typicallycarry sialic acid-bearing sugar chains, which can modify the observed molecular weights and isoelectric points of those proteins during electrophoretic analyses. To explore changes in protein expression and glycosylation that occurred during great ape and human evolution, we subjected multiple blood plasma samples from all these species to high-resolution proteomic analysis. We found very few species-specific differences, indicating a remarkabledegree of conservation of plasma protein expression and glycosylation during similar to 12 million years of evolution. A few lineage-specific differences in protein migration were noted among the great apes. The only obviousdifferences between humans and all great apes were an apparent decrease intransthyretin (prealbumin) and a change in haptoglobin isoforms (the latter was predictable from prior genetic studies). Quantitative studies of transthyretin in samples of blood plasma (synthesized primarily by the liver) and of cerebrospinal fluid (synthesized locally by the choroid plexus of thebrain) confirmed similar to2-fold higher levels in chimpanzees compared tohumans. Since transthyretin binds thyroid hormones, we next compared plasma thyroid hormone parameters between humans and chimpanzees. The results indicate significant differences in the status of thyroid hormone metabolism,which represent the first known endocrine difference between these species. Notably, thyroid hormones are known to play major roles in the development, differentiation, and metabolism of many organs and tissues, including the brain and the cranium. Also, transthyretin is known to be the major carrier of thyroid hormone in the cerebrospinal fluid, likely regulating delivery of this hormone to the brain. A potential secondary difference in retinoid (vitamin A) metabolism is also noted. The implications of these findings for explaining unique features of human evolution are discussed. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:05:40