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Titolo:
Brief research communication - No evidence of an association between 5HT1Breceptor gene polymorphism and suicide victims in a Japanese population
Autore:
Nishiguchi, N; Shirakawa, O; Ono, H; Nishimura, A; Nushida, H; Ueno, Y; Maeda, K;
Indirizzi:
Kobe Univ, Sch Med, Dept Psychiat & Neurol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Sch Med, Dept Legal Med, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 Legal Med, Kobe, Hyogo 6500017, Japan Shiga Univ Med Sci, Dept Legal Med, Ohtsu, Shiga, Japan Shiga Univ Med Sci Ohtsu Shiga Japan Dept Legal Med, Ohtsu, Shiga, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 105, anno: 2001,
pagine: 343 - 345
SICI:
0148-7299(20010508)105:4<343:BRC-NE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN; SCHIZOPHRENIA; 5-HT1D-BETA;
Keywords:
5HT1B receptor; suicide victims; association study; aggression; impulsivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Shirakawa, O Kobe Univ, Sch Med, Dept Psychiat & Neurol, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 6500017 , Japan
Citazione:
N. Nishiguchi et al., "Brief research communication - No evidence of an association between 5HT1Breceptor gene polymorphism and suicide victims in a Japanese population", AM J MED G, 105(4), 2001, pp. 343-345

Abstract

Serotonergic systems have been reported to mediate the control of aggression and/or impulsivity in humans and to be involved in suicidal behavior. Neurochemical studies showing serotonergic dysfunction in suicide appear to support the functional alteration of serotonergic systems due to gene polymorphisms, Knock-out mice of the 5HT1B receptor gene have been reported to result in increased aggression. We hypothesized that the 5HT1B receptor-mediated serotonergic dysfunction was implicated in suicide through disinhibition of aggression and/or impulsivity. To explore this hypothesis, we examinedthe association between suicide victims who completed suicide and the 5HT1B receptor gene G861C polymorphism. No significant differences in genotype distribution and allele frequencies were found between suicide victims and controls, Though there is the possibility of failing to detect small effects, these results show no evidence of an association between the 5HT1B receptor gene G861C polymorphism and suicide victims in a Japanese population and indicate that it is unlikely that the 5HT1B receptor is implicated in thesusceptibility to suicide. (C) 2001 Wiley-Liss,Inc.

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Documento generato il 25/09/20 alle ore 21:11:07