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Titolo:
Affected sibling pair linkage analysis of qualitative and quantitative traits for schizophrenia on chromosome 22 in a Chinese population
Autore:
Cai, GQ; Li, T; Deng, D; Zhao, JH; Hu, X; Murray, RM; Liu, XH; Sham, PC; Collier, DA;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England W China Univ Med Sci, Dept Psychiat, Chengdu 610041, Peoples R China W China Univ Med Sci Chengdu Peoples R China 610041 041, Peoples R China
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 105, anno: 2001,
pagine: 321 - 327
SICI:
0148-7299(20010508)105:4<321:ASPLAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIO-FACIAL SYNDROME; SUSCEPTIBILITY LOCUS; NEGATIVE SYMPTOMS; POTENTIAL LINKAGE; FOLLOW-UP; FAMILIAL SCHIZOPHRENIA; BIPOLAR DISORDER; PSYCHOSIS; DIMENSIONS; STABILITY;
Keywords:
psychosis; genetics; QTL; symptom dimensions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Collier, DA Inst Psychiat, Dept Psychol Med, De Crespigny Pk,Denmark Hill,London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill LondonEngland SE5 8AF
Citazione:
G.Q. Cai et al., "Affected sibling pair linkage analysis of qualitative and quantitative traits for schizophrenia on chromosome 22 in a Chinese population", AM J MED G, 105(4), 2001, pp. 321-327

Abstract

We performed nonparametric linkage analysis on 136 families with two or more siblings with schizophrenia from Sichuan, southwestern China. In addition to categorical diagnosis, we used quantitative trait information from thePositive and Negative Symptom Scale and the modified Overt Aggression Scale, Categorical analysis using the diagnosis of schizophrenia and a maximum likelihood identity-by-descent method produced scores of close to 6 throughout the whole region tested. Multipoint analysis allowed exclusion of most markers with a relative risk of > 2, but did not exclude the possibility ofa relative risk of < 1.5 for four of the markers. Our results provide no significant evidence for a locus for schizophrenia on chromosome 22, Quantitative linkage analysis using the PANSS-G scale score produced a maximum LODscore of similar to 1.2 with the marker D22S310, using either the Haseman-Elston method or maximum likelihood variance estimation with or without dominance. PANSS-N produced a maximum LOD score of 1.2 at the D22S283 locus. LOD score of about 1 are easily produced by chance. Thus, we conclude that under quantitative trait we also find no evidence of linkage between schizophrenia and markers on chromosome 22 in our Chinese sibling pair sample. (C)2001 Wiley-Liss, Inc.

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Documento generato il 18/01/20 alle ore 02:11:34