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Titolo:
Allelic variation of a BalI polymorphism in the DRD3 gene does not influence susceptibility to bipolar disorder: Results of analysis and meta-analysis
Autore:
Elvidge, G; Jones, I; McCandless, F; Asherson, P; Owen, MJ; Craddock, N;
Indirizzi:
Univ Birmingham, Queen Elizabeth Psychiat Hosp, Dept Psychiat, Birmingham B15 2QZ, W Midlands, England Univ Birmingham Birmingham W Midlands EnglandB15 2QZ W Midlands, England Univ Wales Coll Med, Dept Med Psychol, Cardiff CF4 4XN, S Glam, Wales UnivWales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 105, anno: 2001,
pagine: 307 - 311
SICI:
0148-7299(20010508)105:4<307:AVOABP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-D3 RECEPTOR GENE; MANIC-DEPRESSIVE ILLNESS; NO ASSOCIATION; D3 RECEPTOR; SCHIZOPHRENIA; NEUROTRANSMISSION; TRANSMISSION; METAANALYSIS; SUBSTITUTION; LINKAGE;
Keywords:
dopamine receptor; linkage disequilibrium; RFLP; association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Craddock, N Univ Birmingham, Queen Elizabeth Psychiat Hosp, Dept Psychiat,Birmingham B15 2QZ, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2QZ England
Citazione:
G. Elvidge et al., "Allelic variation of a BalI polymorphism in the DRD3 gene does not influence susceptibility to bipolar disorder: Results of analysis and meta-analysis", AM J MED G, 105(4), 2001, pp. 307-311

Abstract

Bipolar disorder is a major psychiatric illness that has evidence for a significant genetic contribution toward its development. In recent years, theHall RFLP (restriction fragment length polymorphism) in the dopamine D3 receptor gene has been examined as a possible susceptibility factor for both schizophrenia and bipolar disorder. While analysis in schizophrenia has produced examples of increased homozygosity in patients, less encouraging results have been found for bipolar disorder. Recently, however, a family-basedassociation study has found a significant excess of allele 1 and allele 1-containing genotypes in transmitted alleles to bipolar probands over nontransmitted controls. In a large bipolar case control sample (n = 454), we have been unable to replicate the family-based association study (chi-square =0.137, P = 0.71, 1 df) or detect an effect similar to the positive homozygosity findings in schizophrenia (chi-square = 0.463, P = 0.50, 1 df). A metaanalysis of previous association studies also revealed no difference in allele distributions between bipolar patients and controls for this polymorphism in ethnically homogeneous samples (odds ratio, OR,= 1.04; P = 0.60; 95%confidence interval, CI, = 0.89-1.20). In view of this evidence, we conclude that variation at the Ball RFLP is not an important: factor influencing the susceptibility to bipolar disorder. It remains possible, however, that other sequence variations within the DRD3 gene could play a role. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 03/07/20 alle ore 01:26:57