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Titolo:
Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women
Autore:
Barinas-Mitchell, E; Cushman, M; Meilahn, EN; Tracy, RP; Kuller, LH;
Indirizzi:
Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Univ Vermont, Dept Med, Burlington, VT USA Univ Vermont Burlington VT USA niv Vermont, Dept Med, Burlington, VT USA Univ Vermont, Dept Pathol, Burlington, VT USA Univ Vermont Burlington VT USA Vermont, Dept Pathol, Burlington, VT USA Univ Vermont, Dept Pathol, Colchester, VT USA Univ Vermont Colchester VT USA Vermont, Dept Pathol, Colchester, VT USA Univ Vermont, Dept Biochem, Colchester, VT USA Univ Vermont Colchester VTUSA Vermont, Dept Biochem, Colchester, VT USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 11, volume: 153, anno: 2001,
pagine: 1094 - 1101
SICI:
0002-9262(20010601)153:11<1094:SLOCPA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; MIDDLE-AGED WOMEN; ADIPOSE-TISSUE; PLASMA-CONCENTRATION; UNSTABLE ANGINA; INFLAMMATION; MEN; DETERMINANTS; TOMOGRAPHY;
Keywords:
adipose tissue; estrone; hormone replacement therapy; inflammation; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Barinas-Mitchell, E Univ Pittsburgh, Dept Epidemiol, 130 DeSoto St, Pittsburgh, PA 15261 USA Univ Pittsburgh 130 DeSoto St Pittsburgh PA USA 15261
Citazione:
E. Barinas-Mitchell et al., "Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women", AM J EPIDEM, 153(11), 2001, pp. 1094-1101

Abstract

The authors evaluated the cross-sectional and prospective associations between the serum concentration of C-reactive protein and measures of obesity and fat distribution, hormone replacement therapy (HRT) use, and serum sex hormones in postmenopausal women from the Healthy Women Study (Allegheny County, Pennsylvania, 1998). The authors tested the hypothesis that C-reactive protein levels would be higher among HRT users and among women with greater body mass index, waist circumference, or visceral fat. There were 207 women in the study who were greater than or equal to8 years postmenopausal (101 HRT users and 106 HRT nonusers). The median levels of C-reactive proteinwere 3.01 mg/liter in HRT users compared with 1.74 mg/liter in nonusers (p= 0.002). C-reactive protein levels were strongly positively correlated with measures of body size, fatness, fat distribution, and weight gain among HRT users and nonusers. C-reactive protein was also positively correlated with serum estrone levels (r(s) = 0.38) among HRT nonusers. The highest level of C-reactive protein was found among HRT users in the highest quartile of visceral fat (4.29 mg/liter) compared with women not on HRT and in the lowest quartile of visceral fat (0.96 mg/liter). The use of HRT and measures of overall body fatness are important correlates of C-reactive protein among postmenopausal women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:30:58