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Titolo:
Steroids and risk of upper gastrointestinal complications
Autore:
Hernandez-Diaz, S; Rodriguez, LAG;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Spanish Ctr Pharmacoepidemiol Res CEIFE, Madrid, Spain Spanish Ctr Pharmacoepidemiol Res CEIFE Madrid Spain IFE, Madrid, Spain
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 11, volume: 153, anno: 2001,
pagine: 1089 - 1093
SICI:
0002-9262(20010601)153:11<1089:SAROUG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PEPTIC-ULCER DISEASE; ASSOCIATION; METAANALYSIS; EPIDEMIOLOGY; THERAPY;
Keywords:
adrenal cortex hormones; anti-inflammatory agents; cohort studies; gastrointestinal hemorrhage; peptic ulcer; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hernandez-Diaz, S Harvard Univ, Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA Harvard Univ 677 Huntington Ave Boston MA USA02115 USA
Citazione:
S. Hernandez-Diaz e L.A.G. Rodriguez, "Steroids and risk of upper gastrointestinal complications", AM J EPIDEM, 153(11), 2001, pp. 1089-1093

Abstract

Most antiinflammatory drugs have been associated with an increase in uppergastrointestinal complications. However, the literature on steroids is more limited than that on nonsteroidal antiinflammatory drugs (NSAIDs). To estimate the risk of upper gastrointestinal complications associated with use of steroids alone and in combination, a nested case-control analysis was conducted on the General Practice Research Database from the United Kingdom. The authors identified 2,105 cases of upper gastrointestinal complications and 11,500 controls between 1993 and 1998. The adjusted odds ratios associated with current use of oral steroids were 1.8 (95% confidence interval (CI): 1.3, 2.4) for upper gastrointestinal complications overall and 2.4 (95% CI: 1.7, 3.4) for gastric and 1.2 (95% CI: 0.8, 1.9) for duodenal damage. Steroids were similarly associated with bleeding (odds ratio (OR) = 1.8; 95%CI: 1.3, 2.4) and perforations (OR = 1.6; 95% CI: 0.9, 3.1). Simultaneous use of steroids with low-medium and high NSAID doses, respectively, produced odds ratios of 4.0 (95% CI: 1.3, 12.0) and 12.7 (95% CI: 8.2, 26.1), compared with users of none. Whenever possible, antiinflammatory drugs should be given in monotherapy and at the lowest effective dose in order to reduce the risk of upper gastrointestinal complications.

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Documento generato il 22/01/20 alle ore 21:46:53