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Titolo:
Morphological analysis of nevoid melanoma - A study of 20 cases with a review of the literature
Autore:
Zembowicz, A; McCusker, M; Chiarelli, C; Dei Tos, AP; Granter, SR; Calonje, E; McKee, PH;
Indirizzi:
Brigham & Womens Hosp, Dept Pathol, Div Dermatopathol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 atopathol, Boston, MA 02115 USA Massachusetts Gen Hosp, Dept Pathol, Dermatopathol Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 hol Unit, Boston, MA 02114 USA San Martino Hosp, Dept Pathol, Belluno, Italy San Martino Hosp Belluno Italy artino Hosp, Dept Pathol, Belluno, Italy Reg Hosp, Dept Pathol, Treviso, Italy Reg Hosp Treviso ItalyReg Hosp, Dept Pathol, Treviso, Italy St Thomas Hosp, St Johns Inst Dermatol, Dept Dermatopathol, London, England St Thomas Hosp London England atol, Dept Dermatopathol, London, England
Titolo Testata:
AMERICAN JOURNAL OF DERMATOPATHOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 167 - 175
SICI:
0193-1091(200106)23:3<167:MAONM->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIMAL DEVIATION MELANOMA; MALIGNANT-MELANOMA; DIAGNOSIS; FEATURES; NEVUS;
Keywords:
melanoma; minimal deviation melanoma; nevoid melanoma; nevus; small cell melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: McKee, PH Brigham & Womens Hosp, Dept Pathol, Div Dermatopathol, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 2115 USA
Citazione:
A. Zembowicz et al., "Morphological analysis of nevoid melanoma - A study of 20 cases with a review of the literature", AM J DERMAT, 23(3), 2001, pp. 167-175

Abstract

Nevoid melanoma is a rare variant of melanoma characterized by deceptive morphologic features reminiscent of a benign melanocytic nevus. Twenty (13 nodular, 7 verrucous) nevoid melanomas were reviewed with the goal of identifying the predominant architectural patterns, cytologic features, and prognostic indicators. Although at scanning magnification, many lesions showed astrong resemblance to banal compound or dermal nevi, careful inspection inall cases demonstrated subtle pleomorphism and impaired maturation with depth, invariably accompanied by multiple dermal mitoses. Four tumors recurred and three metastasized, with subsequent death of the patients. Follow-up information for a period of at least 3 years was available in eight cases. In this group, mortality was 37.5%, the metastasis rate was 37.5%, and the local recurrence rate was 75%, with an average tumor thickness of 2.5 mm. We conclude that nevoid melanoma may be distinguished from a benign melanocytic nevus by a high index of suspicion, a careful analysis of architecture,and attention to cytologic features. Our data and a review of the literature do not support the notion that nevoid melanoma has a better prognosis than ordinary melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 05:54:31