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Titolo:
The enhanced anticaries efficacy of a sodium fluoride and dicalcium phosphate dihydrate dentifrice in a dual-chambered tube. A 2-year caries clinicalstudy on children in the United States of America
Autore:
Boneta, AE; Neesmith, A; Mankodi, S; Berkowitz, HJ; Sanchez, L; Mostler, K; Stewart, B; Sintes, J; DeVizio, W; Petrone, ME; Volpe, AR; Zhang, YP; McCool, JJ; Bustillo, E; Proskin, HM;
Indirizzi:
Univ Puerto Rico, Sch Dent, San Juan, PR 00936 USA Univ Puerto Rico San Juan PR USA 00936 , Sch Dent, San Juan, PR 00936 USA Dent Prod Testing Inc, W Palm Beach, FL USA Dent Prod Testing Inc W Palm Beach FL USA ting Inc, W Palm Beach, FL USA Colgate Palmol Technol Ctr, Clin Dent Res Dept, Piscataway, NJ USA ColgatePalmol Technol Ctr Piscataway NJ USA es Dept, Piscataway, NJ USA Howard M Proskin & Associates Inc, Rochester, NY USA Howard M Proskin & Associates Inc Rochester NY USA nc, Rochester, NY USA
Titolo Testata:
AMERICAN JOURNAL OF DENTISTRY
, volume: 14, anno: 2001,
pagine: 13A - 17A
SICI:
0894-8275(200105)14:<13A:TEAEOA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLAQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Boneta, AE Univ Puerto Rico, Sch Dent, Med Sci Campus, San Juan, PR 00936 USA Univ Puerto Rico Med Sci Campus San Juan PR USA 00936 00936 USA
Citazione:
A.E. Boneta et al., "The enhanced anticaries efficacy of a sodium fluoride and dicalcium phosphate dihydrate dentifrice in a dual-chambered tube. A 2-year caries clinicalstudy on children in the United States of America", AM J DENT, 14, 2001, pp. 13A-17A

Abstract

(Purpose) under bar: To clinically evaluate and compare a dentifrice system in a dual-chambered tube, wherein one chamber contained sodium fluoride in a silica base and the other chamber contained dicalcium phosphate dihydrate (Test Dentifrice delivering 0.243% sodium fluoride), to a dentifrice containing 0.243% sodium fluoride in a silica base (Positive Control Dentifrice). (Materials and Methods) under bar: This study was conducted in harmony with the published 1988 American Dental Association guidelines for studies geared toward the comparison of fluoride dentifrices. This 2-yr caries clinical study employed a double-blind, parallel-group design, and involved 5-17 yr-old children from the Central and South areas of Florida and from the Lares area of Puerto Rico. Qualifying subjects were stratified according toage and sex, and were randomly assigned to the two treatment groups, with multiple subjects in the same household all assigned to the dentifrice randomly allocated to the first among them. Caries examinations were conducted in accordance with U.S. Food and Drug Administration guidelines for the clinical evaluation of drugs to prevent dental caries. Two calibrated examiners performed all the measurements. After treatment assignment, study participants were instructed to brush their teeth at home with their assigned dentifrice at least twice daily. Brushing instructions were reinforced by indoctrination in proper oral hygiene techniques by dental professionals, supplemented by pamphlets supplied by the sponsor and yearly mailings to participants, emphasizing good oral hygiene and the need to enforce compliance withthe study. Post-baseline examinations were performed after 1 yr of productuse, and again after 2 yrs of product use. (Results) under bar: Two thousand five hundred six (2,506) subjects completed this 2-yr study. For these subjects, the mean caries scores (DMFS, decayed, missing and filled tooth surfaces) at baseline were 2.29 for the Test Dentifrice group, and 2.47 for the Positive Control Dentifrice group. For caries increments after 1 yr, therespective means were 0.69 for the Test Dentifrice group and 0.81 for the Positive Control Dentifrice group. Finally, after 2 yrs, the mean caries increments were 1.25 for the Test Dentifrice group, and 1.46 for the PositiveControl Dentifrice group. No statistically significant difference was indicated between the treatment groups at baseline or between the l-yr caries increment scores. However, there was a statistically significant difference in the 2-yr caries increment scores between the treatment groups. Relative to the Positive Control Dentifrice group, the Test Dentifrice group presented a 14.38% reduction in caries increment scores at 2 yrs. In accordance with the procedures and standards provided by the published guidelines of theAmerican Dental Association for the comparison of the anticaries efficacy of fluoride dentifrices, the results of this study support the conclusion that the dentifrice system in a dual-chambered tube, wherein one chamber contained sodium fluoride in a silica base and the other chamber contained dicalcium phosphate dihydrate, delivering 0.243% sodium fluoride, provided a superior level of anticaries efficacy than did the dentifrice containing 0.243% sodium fluoride in a silica base.

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Documento generato il 23/09/18 alle ore 09:05:36